For chemists and material scientists, a thorough understanding of chemical properties is fundamental to successful application and synthesis. 1-Benzylindole-3-carboxylic Acid (CAS 27018-76-4) is a molecule of significant interest due to its utility as a chemical intermediate, particularly in the pharmaceutical and fine chemical industries. This article provides insights into its key characteristics, typical appearance, and synthesis pathways, from the perspective of a chemical manufacturer and supplier.

1-Benzylindole-3-carboxylic Acid, with the molecular formula C16H13NO2, is typically presented as a light yellow to brown solid. Its melting point, commonly reported in the range of 195-196°C, is a critical parameter for quality control and application suitability. As a supplier, we ensure that our product meets this specification, along with a guaranteed purity of 95%min, making it reliable for demanding organic syntheses. Its structure, featuring an indole core substituted with a benzyl group at the N1 position and a carboxylic acid at the C3 position, makes it a versatile precursor for a range of complex molecules.

The synthesis of 1-Benzylindole-3-carboxylic Acid typically involves the benzylation of indole-3-carboxylic acid. A common method includes reacting indole-3-carboxylic acid with a base, such as sodium hydride, followed by treatment with benzyl bromide in a suitable solvent like N,N-Dimethylformamide (DMF). The reaction is usually carried out under controlled conditions, followed by extraction and purification steps, often involving recrystallization from solvents like ether to yield the desired product. As a manufacturer, we employ optimized synthesis protocols to ensure high yields and purity.

The applications of 1-Benzylindole-3-carboxylic Acid are diverse, serving as a key reactant in the preparation of various biologically active compounds. It is instrumental in synthesizing indoleacetic acid analogs that exhibit antiproliferative properties, as well as indole-carboxamide derivatives that act as inhibitors of lipid peroxidation and superoxide anion formation. Understanding these applications helps researchers and formulators identify the potential of this intermediate. For those looking to purchase this compound, seeking a reliable supplier in China that can offer competitive prices and consistent quality is advisable.