Understanding 1-Bromo-1-Butyne: Properties, Synthesis, and Safety
In the field of chemistry, intermediates are the unsung heroes that facilitate the creation of more complex and valuable compounds. 1-Bromo-1-Butyne, a compound with the CAS number 50405-39-5, is a prime example of such an intermediate, particularly significant in pharmaceutical synthesis and broader organic chemistry applications. This article delves into its properties, its role in synthesis, and the critical safety considerations associated with its use.
The chemical identity of 1-Bromo-1-Butyne is characterized by its molecular formula C4H5Br and a molecular weight of 132.98600. It is typically found as a light yellow liquid, a characteristic that aids in its visual identification. Its high purity, often specified at a minimum of 97%, makes it suitable for demanding synthetic procedures. Key physical properties include a density of 1.461 g/cm³ and a flash point of 21.683°C. These figures are crucial for chemists and engineers when designing reaction setups and implementing safety protocols. The compound's stability is best maintained through sealed storage in a cool, dry warehouse, protecting it from moisture and potential degradation.
As a pharmaceutical intermediate, 1-Bromo-1-Butyne is extensively used in the synthesis of Active Pharmaceutical Ingredients (APIs). The presence of both a bromine atom and an alkyne group provides multiple avenues for chemical reactions. The bromine atom is an excellent leaving group, readily participating in nucleophilic substitution reactions. The alkyne moiety, on the other hand, can undergo various addition reactions, coupling reactions, and cycloadditions, enabling the construction of diverse and complex molecular structures. For manufacturers looking to buy 1-Bromo-1-Butyne, sourcing from reliable producers in China, such as NINGBO INNO PHARMCHEM CO.,LTD., ensures access to a high-quality product that can streamline synthetic pathways and improve overall efficiency.
The application of 1-Bromo-1-Butyne in organic synthesis is widespread. It serves as a valuable building block for researchers developing new chemical entities, fine chemicals, and specialty materials. Its predictable reactivity allows for its incorporation into intricate synthetic routes, contributing to the advancement of chemical science. When procuring this chemical, emphasis should be placed on suppliers who provide comprehensive documentation, including safety data sheets (SDS), which detail hazard information and recommended handling procedures.
Safety is a paramount concern when working with any chemical intermediate. Due to its flash point, 1-Bromo-1-Butyne is a flammable liquid and vapor. Therefore, it must be kept away from heat, sparks, open flames, and hot surfaces. Adequate ventilation, the use of personal protective equipment (PPE) such as gloves and eye protection, and proper storage away from incompatible materials are essential. By understanding and adhering to these safety guidelines, users can harness the synthetic power of 1-Bromo-1-Butyne responsibly and effectively.
The chemical identity of 1-Bromo-1-Butyne is characterized by its molecular formula C4H5Br and a molecular weight of 132.98600. It is typically found as a light yellow liquid, a characteristic that aids in its visual identification. Its high purity, often specified at a minimum of 97%, makes it suitable for demanding synthetic procedures. Key physical properties include a density of 1.461 g/cm³ and a flash point of 21.683°C. These figures are crucial for chemists and engineers when designing reaction setups and implementing safety protocols. The compound's stability is best maintained through sealed storage in a cool, dry warehouse, protecting it from moisture and potential degradation.
As a pharmaceutical intermediate, 1-Bromo-1-Butyne is extensively used in the synthesis of Active Pharmaceutical Ingredients (APIs). The presence of both a bromine atom and an alkyne group provides multiple avenues for chemical reactions. The bromine atom is an excellent leaving group, readily participating in nucleophilic substitution reactions. The alkyne moiety, on the other hand, can undergo various addition reactions, coupling reactions, and cycloadditions, enabling the construction of diverse and complex molecular structures. For manufacturers looking to buy 1-Bromo-1-Butyne, sourcing from reliable producers in China, such as NINGBO INNO PHARMCHEM CO.,LTD., ensures access to a high-quality product that can streamline synthetic pathways and improve overall efficiency.
The application of 1-Bromo-1-Butyne in organic synthesis is widespread. It serves as a valuable building block for researchers developing new chemical entities, fine chemicals, and specialty materials. Its predictable reactivity allows for its incorporation into intricate synthetic routes, contributing to the advancement of chemical science. When procuring this chemical, emphasis should be placed on suppliers who provide comprehensive documentation, including safety data sheets (SDS), which detail hazard information and recommended handling procedures.
Safety is a paramount concern when working with any chemical intermediate. Due to its flash point, 1-Bromo-1-Butyne is a flammable liquid and vapor. Therefore, it must be kept away from heat, sparks, open flames, and hot surfaces. Adequate ventilation, the use of personal protective equipment (PPE) such as gloves and eye protection, and proper storage away from incompatible materials are essential. By understanding and adhering to these safety guidelines, users can harness the synthetic power of 1-Bromo-1-Butyne responsibly and effectively.
Perspectives & Insights
Logic Thinker AI
“The bromine atom is an excellent leaving group, readily participating in nucleophilic substitution reactions.”
Molecule Spark 2025
“The alkyne moiety, on the other hand, can undergo various addition reactions, coupling reactions, and cycloadditions, enabling the construction of diverse and complex molecular structures.”
Alpha Pioneer 01
“For manufacturers looking to buy 1-Bromo-1-Butyne, sourcing from reliable producers in China, such as NINGBO INNO PHARMCHEM CO.”