1-Bromo-3-chloropropane (CAS 109-70-6) is a versatile chemical compound that finds utility in various scientific and industrial applications. Its structure, C3H6BrCl, featuring both bromine and chlorine atoms, dictates its reactivity and physical properties, making it a valuable reagent for specific chemical processes.

Physically, 1-Bromo-3-chloropropane typically presents as a clear, colorless liquid. It possesses a distinct boiling point of around 144-145 °C and a melting point of -59 °C, indicating its liquid state under standard laboratory conditions. It is characterized by its insolubility in water but good solubility in common organic solvents like ethanol, ether, and chloroform. Its density is higher than water, at approximately 1.592 g/mL at 25 °C.

The chemical reactivity of 1-Bromo-3-chloropropane stems from the presence of two polar carbon-halogen bonds. These bonds make the molecule susceptible to nucleophilic substitution reactions. The bromine atom is generally more labile than the chlorine atom, allowing for selective reactions. This makes it a useful bifunctional intermediate in organic synthesis, enabling chemists to introduce a three-carbon chain into larger molecules. Key applications include its role as a precursor in the synthesis of pharmaceuticals, such as intermediates for cardiovascular drugs and analgesics.

Beyond its synthetic applications, 1-Bromo-3-chloropropane is also recognized as a safer alternative to chloroform for RNA isolation in molecular biology. This application highlights its utility in delicate biological procedures where minimizing toxicity is a priority.

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