Navigating the complex world of chemical sourcing requires a clear understanding of product specifications, applications, and reliable supply channels. 1-Chloro-3-iodobenzene, identified by its CAS number 625-99-0, is a specialty chemical intermediate with significant utility, particularly in the pharmaceutical and organic synthesis sectors. This article aims to provide a comprehensive overview for procurement professionals and researchers seeking to understand and acquire this compound.

What is 1-Chloro-3-iodobenzene?

1-Chloro-3-iodobenzene is a halogenated aromatic compound characterized by a benzene ring substituted with a chlorine atom and an iodine atom at the meta (1,3) positions. Its molecular formula is C6H4ClI, and it typically presents as a clear to pale yellow liquid. The compound's unique structure, with two different halogens on the same aromatic ring, imparts distinct chemical properties that make it highly valuable in synthesis.

Key Properties and Reactivity

The primary characteristic that makes 1-Chloro-3-iodobenzene so useful is the differential reactivity of its halogen substituents. The carbon-iodine bond is generally more reactive in palladium-catalyzed cross-coupling reactions (like Suzuki, Heck, or Sonogashira couplings) compared to the carbon-chlorine bond. This allows for selective, stepwise functionalization of the molecule. This 'orthogonal reactivity' is crucial for chemists aiming to build complex molecular architectures without resorting to elaborate protecting group strategies.

Applications Across Industries

The versatility of 1-Chloro-3-iodobenzene lends itself to several critical applications:

  • Pharmaceutical Intermediates: It serves as a key building block for synthesizing various active pharmaceutical ingredients (APIs), particularly those requiring specific halogenated aromatic motifs. Its use in creating scaffolds for antiviral and anticancer drugs is well-documented.
  • Organic Synthesis: Beyond pharmaceuticals, it is a staple in academic and industrial research for constructing intricate organic molecules. Its dual halogen functionality enables diverse coupling and substitution reactions.
  • Materials Science: It can be utilized in the synthesis of precursors for advanced materials such as liquid crystals and components for organic electronics like OLEDs.

Sourcing 1-Chloro-3-iodobenzene: Where to Buy

For businesses looking to purchase 1-Chloro-3-iodobenzene, identifying a reliable supplier is crucial. China is a significant global source for such chemical intermediates. When seeking to buy, prospective clients should look for:

  • Reputable Manufacturers: Companies with established production facilities and a history of quality.
  • Product Purity: Ensure the product meets the required purity standards (e.g., 98% or higher) and is accompanied by a Certificate of Analysis (COA).
  • Competitive Pricing: Obtain quotes from multiple suppliers to ensure favorable pricing, especially for larger quantities.
  • Consistent Supply: Verify the supplier's capacity and reliability to meet ongoing demand.

We are a leading manufacturer and supplier of high-quality specialty chemicals, including 1-Chloro-3-iodobenzene (CAS 625-99-0). Our commitment to rigorous quality control and customer service makes us a trusted partner for your chemical sourcing needs. We offer competitive pricing and reliable delivery. Contact us today to learn more and to request a quote for your next order.