Understanding 1-Methyl-3-pyrrolidinol (CAS 13220-33-2) in Chemical Synthesis
The field of chemical synthesis is constantly seeking versatile building blocks that can facilitate the creation of complex and functional molecules. Among these, 1-Methyl-3-pyrrolidinol (CAS 13220-33-2) stands out as a significant intermediate, particularly within the pharmaceutical and fine chemical sectors. Its unique chemical structure, characterized by a pyrrolidine ring with a hydroxyl group and a methyl substituent, makes it an attractive starting material for a wide array of synthetic transformations.
Chemically identified as 1-Methyl-3-pyrrolidinol or N-Methyl-3-pyrrolidinol, this compound bears the CAS number 13220-33-2. Its molecular formula is C5H11NO, with a molecular weight of 101.15. The appearance is typically a colorless oil, which is a common characteristic for many organic intermediates. The presence of the hydroxyl group offers a site for esterification, etherification, or oxidation reactions, while the tertiary amine in the pyrrolidine ring can participate in various reactions, including quaternization or as a nucleophile.
In terms of applications, 1-Methyl-3-pyrrolidinol serves as a critical intermediate in the synthesis of pharmaceuticals. Researchers and formulators utilize it to construct more complex molecular architectures that form the basis of many drugs. Its utility extends to various fields, including potentially agrochemicals and specialty materials, depending on the specific downstream reactions and targets. For scientists engaged in drug discovery, having access to reliable sources of high-purity intermediates like this is crucial for reproducible and successful experimental outcomes. Understanding how to purchase this chemical from reputable manufacturers is key.
When scientists look to buy 1-Methyl-3-pyrrolidinol, they often search for suppliers who can guarantee consistent quality and purity. Specifications such as boiling point (e.g., 50-52 °C at 1 mm Hg) and density (0.921 g/mL at 25 °C) are important parameters that researchers consider. The refractive index (n20/D 1.464) also provides a valuable physical characteristic for quality control. For those needing this intermediate for R&D, finding suppliers that offer convenient packaging and readily available technical data is beneficial. The ability to obtain price quotes efficiently from manufacturers or their authorized distributors simplifies the procurement process.
The chemical industry, particularly in regions like China, has a strong manufacturing base for such intermediates. Companies specializing in fine chemicals and pharmaceutical intermediates often list products like 1-Methyl-3-pyrrolidinol with detailed technical specifications and competitive pricing. Researchers and procurement specialists can find these suppliers through online chemical directories or by directly searching for '1-Methyl-3-pyrrolidinol manufacturer' or 'CAS 13220-33-2 price'. Ensuring the supplier has a robust quality management system, such as ISO certification, can provide an added layer of confidence in the product's reliability.
In summary, 1-Methyl-3-pyrrolidinol (CAS 13220-33-2) is an indispensable intermediate in modern chemical synthesis. Its versatile chemical nature and critical role in creating pharmaceuticals and other fine chemicals underscore its importance. By understanding its properties and strategically sourcing it from qualified manufacturers and suppliers, researchers and industry professionals can effectively advance their projects and product development goals.
Perspectives & Insights
Chem Catalyst Pro
“The appearance is typically a colorless oil, which is a common characteristic for many organic intermediates.”
Agile Thinker 7
“The presence of the hydroxyl group offers a site for esterification, etherification, or oxidation reactions, while the tertiary amine in the pyrrolidine ring can participate in various reactions, including quaternization or as a nucleophile.”
Logic Spark 24
“In terms of applications, 1-Methyl-3-pyrrolidinol serves as a critical intermediate in the synthesis of pharmaceuticals.”