For professionals in the chemical industry, a thorough understanding of the properties and safe handling of chemical intermediates is paramount. 2,2-Difluoroethanol (CAS 359-13-7) is a valuable compound with specific characteristics that dictate its effective and safe use in research and manufacturing. This article aims to provide a detailed overview of its key properties, enabling users to make informed decisions when purchasing or working with this essential fluorinated intermediate.

Physical and Chemical Properties of 2,2-Difluoroethanol

2,2-Difluoroethanol, also known by synonyms such as 2,2-difluoroethan-1-ol, is typically presented as a colorless to light yellow liquid. Its molecular formula is C2H4F2O, with a molecular weight of approximately 82.05 g/mol. These fundamental characteristics are the starting point for understanding its behavior in various applications.

Key properties include:

  • Boiling Point: Approximately 95 °C, indicating it is a relatively volatile liquid.
  • Melting Point: Around -28 °C, meaning it remains liquid even at relatively low temperatures.
  • Density: Approximately 1.296 g/cm³, which is higher than water.
  • Refractive Index: Around 1.338.
  • Solubility: It is soluble in common organic solvents like chloroform and ethanol, facilitating its use in diverse reaction media.
  • Flammability: A critical property is its low flash point, typically around 0.4 °C to 3 °C, classifying it as a flammable liquid. This necessitates careful handling, storage away from ignition sources, and use in well-ventilated areas.

The presence of two fluorine atoms on the second carbon atom of the ethanol backbone significantly influences its chemical reactivity. These electronegative fluorine atoms increase the acidity of the hydroxyl proton compared to non-fluorinated alcohols. This electronic effect can influence hydrogen bonding capabilities and reactivity in various synthetic transformations. When seeking to buy 2,2-difluoroethanol, understanding these chemical nuances helps in planning synthesis routes.

Safe Handling and Storage Guidelines

Given its flammable nature and potential irritant properties (affecting skin, eyes, and respiratory system), strict adherence to safety protocols is essential when handling 2,2-Difluoroethanol. Users should always consult the Safety Data Sheet (SDS) provided by the manufacturer or supplier.

Key safety recommendations include:

  • Personal Protective Equipment (PPE): Always wear appropriate chemical-resistant gloves, safety goggles, and protective clothing. If there is a risk of vapor inhalation, use a respirator with suitable cartridges.
  • Ventilation: Work in a well-ventilated area, preferably under a fume hood, to minimize exposure to vapors.
  • Ignition Sources: Keep away from heat, sparks, open flames, and hot surfaces. Ensure electrical equipment is explosion-proof.
  • Storage: Store in a tightly closed container in a cool, dry, and well-ventilated place, away from incompatible materials. Recommended storage temperatures are often at or below 2-8 °C for long-term stability, though ambient storage may be acceptable for short periods, always referencing the supplier's recommendations.
  • Spill Management: In case of spills, use absorbent materials and ensure proper disposal according to local regulations.

For procurement managers and R&D scientists, sourcing from a reputable 2,2-Difluoroethanol manufacturer in China ensures not only product quality but also access to accurate safety information. When you purchase 2,2-difluoroethanol, always ensure you receive comprehensive documentation.

By understanding and respecting these properties and handling guidelines, professionals can safely and effectively utilize 2,2-Difluoroethanol as a critical intermediate in their diverse chemical synthesis endeavors.