In the realm of fine chemicals and intermediates, 2,4-Dichloropyrimidine (CAS 3934-20-1) holds a significant position due to its versatile chemical nature and broad applicability. For chemical synthesis professionals, understanding this compound's properties, applications, and how to procure it efficiently is key to driving innovation in pharmaceutical, agrochemical, and other related industries. This guide provides a detailed look at 2,4-Dichloropyrimidine.

Chemical Profile and Properties

2,4-Dichloropyrimidine is a heterocyclic organic compound with the molecular formula C4H2Cl2N2 and a molecular weight of 148.98 g/mol. Its key physical characteristics include an appearance as an off-white solid, with a melting point typically ranging from 57-61 °C. The compound's chemical structure features a pyrimidine ring substituted with two chlorine atoms at the 2 and 4 positions, making these chlorine atoms susceptible to nucleophilic substitution. This reactivity is the basis of its utility in numerous synthetic pathways.

Key Applications in Industry and Research

The primary value of 2,4-Dichloropyrimidine lies in its role as a versatile intermediate in chemical synthesis:

  • Pharmaceutical Synthesis: It is a vital building block for synthesizing a wide array of Active Pharmaceutical Ingredients (APIs). Its structure is incorporated into compounds with potential antiviral, anticancer, and anti-inflammatory properties. Its ability to participate in reactions like Suzuki coupling is essential for creating complex pharmaceutical molecules.
  • Agrochemicals: The compound serves as a precursor for the synthesis of various herbicides and fungicides. These agrochemicals play a crucial role in crop protection and enhancing agricultural productivity.
  • Organic Synthesis Research: As a standard reagent in organic chemistry laboratories, it is used for exploring new reaction methodologies, synthesizing novel compounds, and as a starting material for diverse organic transformations like alkylation and amination.

Procurement: Finding Quality Suppliers and Competitive Pricing

For researchers and industrial buyers, sourcing high-quality 2,4-Dichloropyrimidine is a critical step. When looking to buy this compound, it's important to consider:

  • Purity Standards: Aim for suppliers offering a purity of 98.0% or higher, confirmed by reliable analytical methods such as HPLC.
  • Supplier Reputation: Choose manufacturers and distributors with a proven track record for quality and reliability. Many leading suppliers are based in China, offering competitive pricing and efficient global distribution.
  • Documentation: Ensure suppliers provide comprehensive documentation, including Safety Data Sheets (SDS) and Certificates of Analysis (CoA), to verify product specifications and safety information.
  • Packaging and Delivery: For bulk orders, confirm packaging options (e.g., 25kg drums) and inquire about delivery timelines to meet your project schedules.

By understanding the chemical properties and applications of 2,4-Dichloropyrimidine and by partnering with reputable manufacturers and suppliers, organizations can effectively leverage this crucial intermediate to advance their research and production goals.