In the complex world of chemical manufacturing, certain compounds stand out due to their critical role in various industrial applications. For the pharmaceutical sector, intermediates are the unsung heroes that pave the way for life-saving drugs. One such vital compound is 2-Acetyl-3-fluoropyridine (CAS: 87674-20-2). This article provides a detailed overview of its chemical characteristics, its significant applications, and practical advice for procurement professionals and researchers looking to source this essential material.

Chemical Profile and Physical Properties

2-Acetyl-3-fluoropyridine is an organic compound belonging to the family of fluorinated pyridines. Its chemical name is 1-(3-fluoropyridin-2-yl)ethanone, and it is characterized by the molecular formula C7H6FNO and a molecular weight of approximately 139.13 g/mol. Typically presented as a white crystalline powder, it possesses a density of around 1.175 g/cm³ and a boiling point of approximately 179.7°C at standard atmospheric pressure (760 mmHg). Its flash point is around 62.5°C. These properties indicate that it is a relatively stable solid under standard storage conditions, provided it is kept in a tightly closed container in a cool, dry environment. Its refractive index is noted at 1.492.

Key Applications in the Pharmaceutical Industry

The primary and most significant application of 2-Acetyl-3-fluoropyridine is its role as a pharmaceutical intermediate. It serves as a foundational building block in the synthesis of Active Pharmaceutical Ingredients (APIs). The presence of the fluorine atom is particularly advantageous, as it can enhance the pharmacological properties of the final drug molecule, such as improving metabolic stability, increasing oral bioavailability, and modulating receptor binding. This makes it a sought-after component for developing new therapeutic agents targeting a wide spectrum of diseases.

Sourcing 2-Acetyl-3-fluoropyridine: What Buyers Need to Know

For businesses that need to purchase 2-Acetyl-3-fluoropyridine, finding a reliable and quality-conscious supplier is crucial. When you search for a 2-Acetyl-3-fluoropyridine manufacturer, particularly one based in China, several aspects should be prioritized. Firstly, ensure the purity level meets your project's requirements, with ≥98.0% being a common standard for pharmaceutical applications. Secondly, evaluate the supplier's manufacturing capacity, their quality control procedures, and their adherence to international standards. Requesting a Certificate of Analysis (CoA) for each batch is a standard practice to verify the product’s specifications.

The global supply chain for fine chemicals and intermediates is robust, with China playing a pivotal role. Many reputable companies in China specialize in producing and exporting compounds like 2-Acetyl-3-fluoropyridine, offering competitive pricing and efficient logistics. When you inquire about 2-Acetyl-3-fluoropyridine price, consider the total value proposition, which includes product quality, supply reliability, and customer service. Engaging with a seasoned 2-Acetyl-3-fluoropyridine supplier can ensure that your R&D and manufacturing processes proceed smoothly.

In summary, 2-Acetyl-3-fluoropyridine is a valuable chemical intermediate with vital applications in pharmaceutical synthesis. By understanding its properties and adopting a strategic approach to sourcing from qualified manufacturers and suppliers, companies can effectively leverage this compound to drive innovation in drug development.