In the intricate world of chemical synthesis, understanding the fundamental properties of intermediates is crucial for successful R&D and manufacturing. 2-Bromo-3-fluoropyridine (CAS 40273-45-8) is a compound that has garnered significant attention, particularly within the pharmaceutical industry, owing to its versatile reactivity and utility as a building block. This detailed exploration delves into its key physical and chemical characteristics, alongside insights into its synthesis and handling, providing valuable information for procurement managers and research scientists alike.

2-Bromo-3-fluoropyridine is typically presented as a yellow liquid. Its molecular formula is C5H3BrFN, with a molecular weight of approximately 175.99 g/mol. Key physical properties include a density of around 1.7 g/cm³ and a boiling point of approximately 173.2 °C at standard atmospheric pressure. The flash point of 58.6 °C indicates moderate flammability, necessitating appropriate safety precautions during handling and storage. As a testament to its quality, it is often supplied with a purity of ≥98.0%, ensuring its suitability for demanding applications where precision is paramount.

Chemically, the pyridine ring, substituted with both a bromine atom and a fluorine atom, offers a rich platform for synthetic modifications. The bromine atom, in particular, serves as an excellent leaving group, making the compound highly amenable to various cross-coupling reactions, such as Suzuki, Stille, and Heck couplings. These reactions are instrumental in forming new carbon-carbon bonds, essential for constructing complex molecular architectures found in pharmaceuticals and other fine chemicals. Researchers looking to buy this intermediate can leverage these reactions to create diverse libraries of compounds for screening or to synthesize specific target molecules. As a dedicated manufacturer, we focus on producing this compound with consistent quality.

The fluorine atom contributes to the compound's unique electronic properties and can influence the reactivity of adjacent positions on the pyridine ring, as well as the properties of the final synthesized product, such as lipophilicity and metabolic stability. This makes 2-Bromo-3-fluoropyridine a valuable tool in drug design and agrochemical development. When considering its application, it is important to consult with a knowledgeable supplier to understand its specific reactivity profiles in various reaction conditions. Discussing the price and availability is also a crucial part of the procurement process.

Proper storage is vital for maintaining the quality of 2-Bromo-3-fluoropyridine. It should be kept in a tightly closed container, in a cool, dry, and well-ventilated area, away from direct sunlight and incompatible materials. Adherence to these guidelines by both the manufacturer and the end-user ensures the compound retains its optimal chemical state. For those aiming to purchase this chemical, selecting a provider known for robust packaging and clear handling instructions is highly recommended.

In conclusion, 2-Bromo-3-fluoropyridine is a key intermediate with well-defined physical and chemical properties that make it highly valuable in advanced synthesis. Its dual halogenation offers significant synthetic flexibility, particularly for pharmaceutical and agrochemical applications. We are a reliable supplier committed to providing high-quality 2-Bromo-3-fluoropyridine. We encourage you to contact us for a quotation and to explore how we can support your chemical needs.