As a chemical strategist focusing on B2B markets, understanding the nuances of key intermediates is crucial for driving client success. Today, we delve into 2-Bromothiophene (CAS: 1003-09-4), a versatile compound that serves as a vital link in the production of numerous high-value chemicals, most notably pharmaceuticals. For procurement managers and R&D scientists, a thorough understanding of its properties, applications, and sourcing channels is essential for efficient operations and innovative product development. Let's explore what makes this chemical so important and how you can best secure your supply.

The Chemical Profile of 2-Bromothiophene

2-Bromothiophene is an organic compound characterized by its molecular formula C4H3BrS and a molecular weight of 163.04. It is a halogenated thiophene derivative, presenting as a clear, colorless to pale yellow transparent liquid at room temperature. Key physical properties include a boiling point typically around 149-151 °C and a density of approximately 1.684 g/mL at 25 °C. Importantly, it is immiscible with water but soluble in common organic solvents like ether and acetone. Its flash point is around 140 °F, indicating it is a combustible liquid that requires careful handling and storage away from heat and ignition sources.

The compound's CAS number, 1003-09-4, is universally recognized, making it easy to search for and reference across global supplier networks. When considering a purchase, it's vital to check the purity, which is commonly specified as ≥99.0% or higher, with low water content (≤0.5%).

Applications: Where Does 2-Bromothiophene Shine?

The primary application driving the demand for 2-Bromothiophene is its role as a critical intermediate in the synthesis of pharmaceutical compounds. It is particularly indispensable for manufacturing the antithrombotic drug Clopidogrel and its various salt forms, such as Clopidogrel sulfate (CAS: 120202-66-6) and Clopidogrel camphorsulfonate (CAS: 120202-68-8). This makes it a high-demand product for API manufacturers and contract research organizations (CROs) involved in cardiovascular drug development.

Beyond its well-known pharmaceutical uses, 2-Bromothiophene is also a valuable reagent in general organic synthesis. Researchers utilize it in various coupling reactions, metallation-alkylation processes, and as a building block for creating complex heterocyclic structures, including novel materials for organic electronics or specialized polymers. For those looking to buy 2-bromothiophene for research purposes, understanding its reactivity and handling requirements is key.

Sourcing 2-Bromothiophene: A Buyer's Guide

When you need to purchase 2-Bromothiophene, identifying a reliable manufacturer or supplier is paramount. For B2B buyers, particularly those in regulated industries like pharmaceuticals, due diligence is essential. Look for suppliers that:

  • Provide detailed product specifications and Certificates of Analysis (CoA).
  • Offer competitive pricing and transparent quotation processes.
  • Have robust quality control measures in place.
  • Demonstrate a consistent supply capability (e.g., high monthly supply ability).
  • Have experience in supplying to the pharmaceutical or fine chemical sectors.
  • Offer flexible packaging options, from R&D quantities to bulk industrial drums.

Keywords such as “2-bromothiophene supplier China” or “buy CAS 1003-09-4” are common search terms. However, it’s the supplier's responsiveness, technical support, and commitment to quality that truly differentiate them. For example, a supplier listing “2-bromothiophene price” should also be prepared to discuss their manufacturing standards and delivery logistics.

In essence, 2-Bromothiophene is more than just a chemical; it's an enabler of critical pharmaceutical advancements. By understanding its properties and strategically sourcing it from reputable manufacturers, businesses can ensure the quality and continuity of their production lines and research endeavors.