Understanding 2-Butyl-4-chloro-5-formylimidazole: Properties and Applications
In the realm of fine chemicals and pharmaceutical intermediates, precision and purity are paramount. 2-Butyl-4-chloro-5-formylimidazole (CAS 83857-96-9) is a prime example of a chemical compound whose specific properties make it invaluable in advanced synthesis, particularly within the pharmaceutical sector. Known widely for its role as an intermediate in the production of Losartan, an important antihypertensive drug, this compound embodies the crucial link between basic chemistry and therapeutic outcomes.
The chemical identity of 2-Butyl-4-chloro-5-formylimidazole is defined by its molecular formula C8H11ClN2O and a molecular weight of approximately 186.64 g/mol. Its physical form is typically described as a yellow to light yellow crystalline powder. Key physical properties include a melting point in the range of 97-100 °C, which indicates its solid state under standard conditions. This physical characteristic, along with its solubility in common organic solvents like methanol, contributes to its ease of handling and processing in chemical synthesis.
The primary and most significant application of 2-Butyl-4-chloro-5-formylimidazole is its use as a key intermediate in the synthesis of Losartan potassium. Losartan is a potent angiotensin II receptor blocker (ARB) widely prescribed for managing hypertension. The specific structural features of this imidazole derivative, including the butyl group and the reactive formyl group on the imidazole ring, are essential for building the complex structure of the Losartan molecule through a series of targeted chemical reactions.
Pharmaceutical manufacturers prioritize intermediates that exhibit high purity levels, and 2-Butyl-4-chloro-5-formylimidazole is no exception. Specifications often call for purity exceeding 99%, with strict limits on individual and total impurities. This high standard is critical because any impurities present in the intermediate could potentially carry through to the final API, affecting its safety and efficacy. Manufacturers in China are key suppliers, ensuring that these critical purity standards are met through rigorous quality control processes.
Beyond its primary role in Losartan synthesis, the chemical structure of 2-Butyl-4-chloro-5-formylimidazole suggests potential utility in the synthesis of other related pharmaceutical compounds or as a versatile building block in medicinal chemistry research. Its reactive aldehyde group, coupled with the substituted imidazole ring, offers numerous possibilities for further chemical modification.
The sourcing of such intermediates is a critical aspect of pharmaceutical supply chain management. Companies require reliable suppliers who can provide consistent quality, timely delivery, and comprehensive documentation. Understanding the properties and applications of compounds like 2-Butyl-4-chloro-5-formylimidazole is essential for procurement specialists and R&D scientists alike.
In summary, 2-Butyl-4-chloro-5-formylimidazole is a vital chemical intermediate, underpinning the production of a critical medication for cardiovascular health. Its well-defined properties and essential role in the synthesis of Losartan highlight the indispensable contribution of fine chemical manufacturing to modern medicine.
The chemical identity of 2-Butyl-4-chloro-5-formylimidazole is defined by its molecular formula C8H11ClN2O and a molecular weight of approximately 186.64 g/mol. Its physical form is typically described as a yellow to light yellow crystalline powder. Key physical properties include a melting point in the range of 97-100 °C, which indicates its solid state under standard conditions. This physical characteristic, along with its solubility in common organic solvents like methanol, contributes to its ease of handling and processing in chemical synthesis.
The primary and most significant application of 2-Butyl-4-chloro-5-formylimidazole is its use as a key intermediate in the synthesis of Losartan potassium. Losartan is a potent angiotensin II receptor blocker (ARB) widely prescribed for managing hypertension. The specific structural features of this imidazole derivative, including the butyl group and the reactive formyl group on the imidazole ring, are essential for building the complex structure of the Losartan molecule through a series of targeted chemical reactions.
Pharmaceutical manufacturers prioritize intermediates that exhibit high purity levels, and 2-Butyl-4-chloro-5-formylimidazole is no exception. Specifications often call for purity exceeding 99%, with strict limits on individual and total impurities. This high standard is critical because any impurities present in the intermediate could potentially carry through to the final API, affecting its safety and efficacy. Manufacturers in China are key suppliers, ensuring that these critical purity standards are met through rigorous quality control processes.
Beyond its primary role in Losartan synthesis, the chemical structure of 2-Butyl-4-chloro-5-formylimidazole suggests potential utility in the synthesis of other related pharmaceutical compounds or as a versatile building block in medicinal chemistry research. Its reactive aldehyde group, coupled with the substituted imidazole ring, offers numerous possibilities for further chemical modification.
The sourcing of such intermediates is a critical aspect of pharmaceutical supply chain management. Companies require reliable suppliers who can provide consistent quality, timely delivery, and comprehensive documentation. Understanding the properties and applications of compounds like 2-Butyl-4-chloro-5-formylimidazole is essential for procurement specialists and R&D scientists alike.
In summary, 2-Butyl-4-chloro-5-formylimidazole is a vital chemical intermediate, underpinning the production of a critical medication for cardiovascular health. Its well-defined properties and essential role in the synthesis of Losartan highlight the indispensable contribution of fine chemical manufacturing to modern medicine.
Perspectives & Insights
Nano Explorer 01
“Losartan is a potent angiotensin II receptor blocker (ARB) widely prescribed for managing hypertension.”
Data Catalyst One
“The specific structural features of this imidazole derivative, including the butyl group and the reactive formyl group on the imidazole ring, are essential for building the complex structure of the Losartan molecule through a series of targeted chemical reactions.”
Chem Thinker Labs
“Pharmaceutical manufacturers prioritize intermediates that exhibit high purity levels, and 2-Butyl-4-chloro-5-formylimidazole is no exception.”