For professionals engaged in chemical synthesis, particularly within the pharmaceutical and agrochemical sectors, access to precisely characterized intermediates is fundamental. 2-Chloro-5-fluoro-4-iodopyridine (CAS: 884494-49-9) is a notable example of such a compound, offering a rich chemical profile that supports a wide array of synthetic methodologies. Understanding its properties, applications, and the best practices for its procurement is essential for successful R&D and manufacturing endeavors. When looking to buy this chemical, attention to detail regarding its specifications and supplier reliability is key.

Chemical Specifications and Properties:

2-Chloro-5-fluoro-4-iodopyridine, with the molecular formula C5H2ClFIN, has a molecular weight of approximately 257.43. This solid compound is characterized by its specific arrangement of halogen substituents on a pyridine ring, which dictates its reactivity. Key physical properties include its melting point and boiling point, which are crucial for determining appropriate handling and reaction conditions. The purity of this intermediate is a critical factor, with typical specifications requiring a minimum of 97%. This high purity ensures that reactions proceed cleanly, minimizing side products and facilitating downstream purification. Suppliers often provide detailed analytical data, such as NMR spectra and HPLC chromatograms, to confirm product quality. Understanding these specifications before you decide to buy is a vital step for any R&D scientist.

Applications in Chemical Innovation:

The utility of 2-Chloro-5-fluoro-4-iodopyridine stems from its versatile reactivity, particularly in cross-coupling reactions. The iodine atom is readily displaced in palladium-catalyzed reactions, allowing for the introduction of carbon-based fragments. This makes it an ideal starting material for constructing complex molecular architectures found in many APIs and crop protection agents. Researchers often utilize this compound to synthesize pyridine derivatives with tailored electronic and biological properties. For instance, its incorporation can lead to compounds with enhanced efficacy or improved pharmacokinetic profiles in drug development. Similarly, in agrochemistry, it aids in the creation of more targeted and effective pesticides. Procurement managers seeking to buy this intermediate are typically supporting projects in drug discovery, lead optimization, or the development of next-generation agricultural chemicals.

Sourcing and Purchasing Strategies:

When it comes to purchasing 2-Chloro-5-fluoro-4-iodopyridine, identifying reliable sources is paramount. Manufacturers and suppliers, particularly those based in China, offer competitive pricing and can cater to varying quantity requirements, from research-scale grams to bulk kilograms. It is advisable to obtain multiple quotes and to carefully evaluate potential suppliers based on their product quality, consistency, technical support, and delivery timelines. Prioritizing suppliers who provide comprehensive documentation and adhere to strict quality control protocols will ensure a smooth procurement process. If you are looking to buy for a new project, engaging with potential suppliers early to discuss custom synthesis or bulk pricing options can be highly beneficial.

Conclusion:

2-Chloro-5-fluoro-4-iodopyridine stands as a significant building block in the toolkit of synthetic chemists. Its well-defined chemical properties and broad applicability in creating advanced molecules underscore its importance in pharmaceutical and agrochemical innovation. By focusing on quality specifications and engaging with trusted suppliers, professionals can effectively source this compound and drive their research and development forward.