For professionals in the chemical industry, a thorough understanding of key intermediates like 2-Iodoanisole (CAS: 529-28-2) is fundamental to optimizing research and production processes. This aromatic compound serves as a vital building block in various synthetic pathways, from pharmaceuticals to specialized materials. This article aims to provide a comprehensive overview of its properties, applications, and guidance on how to procure it from reliable sources.

2-Iodoanisole, scientifically known as 1-iodo-2-methoxybenzene, is characterized by its molecular formula C7H7IO and a molecular weight of 234.03 g/mol. Its physical appearance is typically described as a pink-brown to red liquid, though high-purity grades can appear as pale yellow liquids. With a density of approximately 1.7 g/cm³ and a boiling point around 244.9°C at 760 mmHg, it exhibits properties characteristic of substituted aromatic ethers. Its melting point, often cited around 8-10°C, indicates it is a liquid at standard room temperatures.

The primary utility of 2-Iodoanisole lies in its role as a versatile intermediate in organic synthesis. The presence of the iodine atom makes it highly reactive in various coupling reactions, such as palladium-catalyzed cross-couplings, which are cornerstones of modern synthetic chemistry. This reactivity allows chemists to introduce complex functionalities and build intricate molecular structures, making it invaluable in the pharmaceutical sector for synthesizing Active Pharmaceutical Ingredients (APIs) and in material science for creating compounds like liquid crystals.

For businesses looking to buy 2-Iodoanisole, identifying a dependable chemical supplier is a critical step. Key considerations include the purity level (often specified as ≥98.0%), the stability of the supply chain, and the competitive pricing offered by manufacturers. Procurement managers often seek out chemical manufacturers in China due to the extensive production capabilities and cost-effectiveness. When searching for a supplier, it is advisable to request detailed specifications, Certificates of Analysis (CoA), and to compare quotes from multiple sources to ensure the best value and quality.

The safety and handling of 2-Iodoanisole also warrant attention. As with many iodine-containing organic compounds, it is advisable to store it in a cool, ventilated place, protected from light, as it can decompose and precipitate iodine. Adhering to recommended safety precautions during handling is essential. Whether for research laboratories or large-scale industrial synthesis, understanding the complete profile of 2-Iodoanisole and partnering with reliable chemical suppliers ensures efficient and successful outcomes.