In the intricate landscape of chemical synthesis, understanding the precise attributes of each compound is fundamental. For professionals in the pharmaceutical sector, knowledge of critical intermediates like (2-methyl-2-phenyl-propyl) acetate (CAS: 18755-52-7) is indispensable. This compound, also known by synonyms such as Neophyl acetate or Benzeneethanol, b,b-dimethyl-, 1-acetate, plays a crucial role as a building block, most notably in the pharmaceutical industry for the synthesis of Fexofenadine Hydrochloride, a popular non-sedating antihistamine.

The chemical name, (2-methyl-2-phenyl-propyl) acetate, reveals its structure as an ester. Its molecular formula, C12H16O2, and molecular weight of approximately 192.25 g/mol, provide essential data points for chemical calculations. Physically, it is characterized as a white crystalline powder, indicating stability and ease of handling in a manufacturing setting. This form is preferred by many end-users, making it an accessible intermediate to buy and utilize. Key physical properties include a density of around 0.998 g/cm³, a boiling point of 256.8°C at 760 mmHg, and a flash point of 100.8°C, information vital for process safety and planning.

The primary application driving demand for (2-methyl-2-phenyl-propyl) acetate is its function as an intermediate in the production of Fexofenadine hydrochloride (CAS: 138452-21-8). In the multi-step synthesis of this vital API, this acetate derivative serves as a precursor that facilitates the formation of the drug's characteristic side chain. This contribution is critical for achieving the desired pharmacological activity of Fexofenadine, which is its potent antihistaminic effect without sedative side effects.

For procurement managers and R&D scientists, sourcing this compound requires attention to specifications. A purity level of ≥99% is typically sought to ensure the efficiency and quality of the final pharmaceutical product. When looking to purchase from a manufacturer or supplier, it is important to verify their ability to consistently deliver material meeting these high standards. Reliable suppliers often provide detailed technical specifications, including CAS numbers and synonyms, along with appropriate handling and storage recommendations.

Understanding the storage requirements, such as keeping the material in a cool, dry, well-closed container away from moisture and strong light, is crucial for maintaining the quality of (2-methyl-2-phenyl-propyl) acetate. By partnering with reputable chemical manufacturers, pharmaceutical companies can ensure a steady and reliable supply of this vital intermediate, thereby supporting the uninterrupted production of essential medications like Fexofenadine Hydrochloride.