For professionals in the pharmaceutical industry, identifying and securing high-quality chemical intermediates is paramount to successful drug development and manufacturing. Among these critical components, 2-Pyridinecarboxaldehyde (CAS 1121-60-4) stands out as a versatile and indispensable building block. This article delves into why this compound is a cornerstone for many pharmaceutical syntheses and how astute buyers can ensure a reliable supply from leading manufacturers.

What is 2-Pyridinecarboxaldehyde?

2-Pyridinecarboxaldehyde, also known by its common name Picolinaldehyde, is an organic compound characterized by a pyridine ring substituted with a formyl group at the alpha (2-) position. Its molecular formula is C6H5NO, and its CAS number is 1121-60-4. It typically appears as a light yellow to light brown liquid, with a distinct but not overly pungent odor. Its key physical properties include a melting point around -21°C to -22°C and a boiling point of approximately 181°C. Its miscibility with many organic solvents, like ethanol and ether, further enhances its utility in various chemical processes.

Critical Applications in Pharmaceutical Synthesis

The significance of 2-Pyridinecarboxaldehyde in the pharmaceutical sector cannot be overstated. It serves as a crucial raw material for the synthesis of several important drugs. Notably, it is a key intermediate in the production of PAM (Pralidoxime iodide), an organophosphate detoxification drug vital for treating nerve agent poisoning. Additionally, it plays a role in the synthesis of bisacodyl, a widely used stimulant laxative. For manufacturers of these essential medicines, securing a consistent supply of high-purity 2-Pyridinecarboxaldehyde from a reputable supplier is non-negotiable. The demand for 2-Pyridinecarboxaldehyde price stability is a constant concern for procurement managers.

Beyond Pharmaceuticals: Versatility in Organic Chemistry

While its pharmaceutical applications are prominent, 2-Pyridinecarboxaldehyde's utility extends to broader organic synthesis. Its reactive aldehyde group readily undergoes reactions like nucleophilic addition and condensation. The presence of the pyridine ring also imparts unique electronic and steric properties, making it valuable in synthesizing complex heterocyclic compounds, which are prevalent in many biologically active molecules. Researchers exploring new synthetic pathways or developing novel materials often buy 2-Pyridinecarboxaldehyde CAS 1121-60-4 for its wide-ranging reactivity.

Sourcing High-Quality 2-Pyridinecarboxaldehyde: The Manufacturer's Advantage

When you need to purchase 2-Pyridinecarboxaldehyde, partnering with a reliable manufacturer and supplier is key. Leading chemical manufacturers in China, such as those specializing in fine chemical intermediates, offer products that meet stringent quality standards. When you look for an industrial grade 2-Pyridinecarboxaldehyde for sale, consider factors like purity assays (often >98.0% by GC), packaging options (e.g., 25kg/drum), and storage recommendations (cool, dry, well-ventilated). Understanding the 2-Pyridinecarboxaldehyde price manufacturer offers can significantly impact your project budget.

Ensuring Safety and Proper Handling

Like many chemical intermediates, 2-Pyridinecarboxaldehyde requires careful handling and storage. It is classified with hazard statements such as 'Harmful if swallowed' and 'Fatal if inhaled', necessitating appropriate personal protective equipment and well-ventilated working environments. Storage should be in tightly closed containers in a cool, dry place, away from incompatible materials like strong oxidizers. Always consult the Safety Data Sheet (SDS) provided by your 2-Pyridinecarboxaldehyde supplier for detailed safety information.

Conclusion

2-Pyridinecarboxaldehyde is more than just a chemical compound; it's a vital enabler for the pharmaceutical industry and a valuable tool for organic chemists. For businesses seeking to buy 2-Pyridinecarboxaldehyde, focusing on purity, reliability of supply, and competitive pricing from qualified manufacturers and suppliers is crucial. By understanding its properties and applications, procurement professionals can make informed decisions and ensure the seamless integration of this essential intermediate into their operations.