In the rigorous world of Active Pharmaceutical Ingredient (API) manufacturing, the detailed specifications of chemical intermediates are not merely guidelines but critical determinants of success. For the synthesis of Pramipexole, a key intermediate is 2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole, identified by CAS number 106006-83-1. Understanding its precise specifications is vital for R&D scientists, formulation chemists, and procurement managers aiming to ensure product quality and regulatory compliance.

Key Technical Specifications and Their Importance

The material data for 2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole provides crucial insights for its application. The typical 'Appearance' is documented as a 'white powder,' a visual characteristic that aids in initial quality assessment. More critical are the quantitative measures that define its suitability for pharmaceutical synthesis:

  • Purity: A purity level of ≥99% is standard for this intermediate. High purity minimizes the risk of unwanted by-products forming during subsequent reaction steps, which could complicate purification or compromise the final API's safety profile.
  • Related Substances: Limits on 'Related substance' (≤0.5%) ensure that impurities stemming from the intermediate's own synthesis are kept to a minimum.
  • Residue on Ignition: A low percentage (≤0.5%) indicates minimal inorganic impurities or contaminants.
  • Heavy Metals: Strict limits (≤0.002%) are in place to prevent the introduction of toxic heavy metal ions, which are detrimental in pharmaceutical applications.
  • Water Content: Control over water content (≤1.0%) is important for maintaining the stability and reactivity of the compound.

These specifications are crucial when a buyer searches for 'high purity 2,6-diamino-4,5,6,7-tetrahydrobenzothiazole' or 'buy CAS 106006-83-1.' A manufacturer that can consistently meet these standards demonstrates a commitment to quality.

Procurement and Application Context

When you are looking to purchase this intermediate, whether for R&D or bulk manufacturing, always request the full specification sheet and Certificate of Analysis (CoA) from the supplier. This documentation verifies that the product meets the stated quality attributes. For those involved in the synthesis of Pramipexole, understanding how these specifications translate into reaction yields and final API purity is key. For example, the compound's use as an 'intermediate of Pramipexole' highlights its direct role in the drug's molecular construction.

By meticulously adhering to these specifications and partnering with reliable suppliers who can guarantee them, pharmaceutical manufacturers can streamline their production processes and ensure the delivery of safe and effective therapies like Pramipexole. The detailed technical profile of 2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole empowers chemists and procurement specialists to make informed decisions.