For professionals in the chemical synthesis and manufacturing sectors, a thorough understanding of key chemical intermediates is vital. 3-Amino-1,2-propanediol (CAS 616-30-8), also known as Isoserinol, is one such compound that offers significant utility due to its bifunctional nature.

Physical and Chemical Properties:

3-Amino-1,2-propanediol typically presents as a clear, colorless to pale yellow liquid. It is characterized by a high viscosity and a melting point of 55-57 °C, with a boiling point of 264-265 °C at 739 mmHg. Its density is approximately 1.175 g/mL at 25 °C. The compound is soluble in water and possesses a pKa of around 12.11, indicating its basic nature. Its chemical formula is C3H9NO2, and it has a molecular weight of 91.11 g/mol.

Synthesis Methods:

The synthesis of 3-Amino-1,2-propanediol often involves reacting 3-chloro-1,2-propanediol with ammonia. This ammonolysis reaction can be carried out under controlled conditions, sometimes in microreactors, to optimize yield and purity. Alternative routes might involve epichlorohydrin or DL-glyceraldehyde as starting materials, utilizing reagents such as ammonia and sodium hydroxide. Purification steps are crucial to achieve the high purity demanded by end-users, especially in the pharmaceutical industry.

Key Applications:

The versatility of 3-Amino-1,2-propanediol is evident in its widespread applications. It is a key intermediate in the production of:

  • Pharmaceuticals: Notably, in the synthesis of iohexol, a non-ionic contrast agent for medical imaging.
  • Agrochemicals: Used as an intermediate in the formulation of pesticides.
  • Specialty Materials: Its chemical structure makes it suitable for the development of various advanced materials.
  • Emulsifiers: It functions effectively as an emulsifier in various industrial processes.

Sourcing Strategies for Buyers:

Procurement managers seeking to buy 3-Amino-1,2-propanediol should prioritize suppliers who offer consistent quality and reliable supply chains. When evaluating potential manufacturers, consider their production capacity, quality control certifications, and ability to provide detailed product specifications and safety data sheets (SDS). Comparing prices from different suppliers, particularly from established manufacturers in China, can lead to significant cost savings for bulk orders.

As a leading supplier, we are dedicated to providing high-quality 3-Amino-1,2-propanediol that meets rigorous industry standards. Our expertise in chemical synthesis and commitment to customer satisfaction make us an ideal partner for your procurement needs. We encourage you to request a quote or sample to experience the quality and service we offer.