For chemists and researchers engaged in organic synthesis, a thorough understanding of the properties and accessible synthesis routes for key intermediates is fundamental. 3-Amino-2-methylpyridine (CAS 3430-10-2), also known by its synonym 3-amino-2-picoline, is a compound that embodies this importance, serving as a versatile building block across various chemical industries, particularly pharmaceuticals and agrochemicals. This article aims to provide insights into its physical and chemical characteristics, along with common synthesis methodologies.

Physically, 3-Amino-2-methylpyridine typically appears as off-white crystals. Its melting point is generally reported in the range of 114-119°C, indicating its solid state under standard conditions. The molecular formula is C6H8N2, with a molecular weight of approximately 108.14 g/mol. The presence of the amine group (NH2) and the pyridine ring contributes to its chemical behavior. The amine group is a site of nucleophilic activity, readily participating in reactions like acylation, alkylation, and condensation. The pyridine ring, an aromatic heterocycle, offers stability and can undergo electrophilic aromatic substitution, though its reactivity is influenced by the substituents present.

Several synthetic pathways exist for the preparation of 3-Amino-2-methylpyridine, reflecting its demand as a crucial intermediate. One common approach involves the reduction of nitro-pyridine precursors or the amination of halogenated methylpyridines. For instance, nitration of 2-methylpyridine followed by reduction can yield the desired amine. Alternatively, metal-catalyzed amination reactions, such as those employing copper catalysts, can be used to introduce the amino group onto a suitably substituted pyridine ring. The choice of synthesis method often depends on factors such as the availability of starting materials, desired purity, scalability, and cost-effectiveness.

Researchers and manufacturers often focus on optimizing these synthesis routes to achieve higher yields and greater purity, especially for applications in sensitive fields like pharmaceutical intermediate production. Access to reliable information regarding synthesis is crucial for both custom synthesis providers and end-users. For those looking to buy 3-Amino-2-methylpyridine, understanding these underlying chemical principles can aid in sourcing and quality assessment.

As a key intermediate, 3-Amino-2-methylpyridine’s accessibility through efficient synthesis ensures its continued role in the development of new chemical products. Sourcing from reputable manufacturers that specialize in fine chemical intermediates guarantees that you receive a product that meets stringent specifications, supporting your critical research and production needs. When you need to buy this compound, partnering with a reliable supplier in China offers a pathway to high-quality materials at competitive prices.