In the vast landscape of chemical synthesis, understanding the properties and applications of key intermediates is crucial for researchers and industrial professionals alike. 3-Bromo-4-Fluorophenol (CAS 27407-11-0) stands out as a versatile compound, finding utility across pharmaceuticals, agrochemicals, and materials science. This article aims to provide a comprehensive overview of its synthesis, physicochemical characteristics, and the diverse applications that make it a valuable commodity for chemical procurement and R&D.

Physicochemical Properties and Appearance:
3-Bromo-4-Fluorophenol, with the molecular formula C₆H₄BrFO and a molecular weight of approximately 191.00 g/mol, typically presents as a yellow oil or light yellow to yellow crystalline powder, depending on its purity and ambient temperature. Its reported density is around 1.76 g/cm³, and it has a boiling point of approximately 240.5 °C at 760 mmHg. The flash point is around 99.2 °C. These properties are critical for handling, storage, and reaction design. For procurement managers, understanding these specifications is key to ensuring compatibility with existing processes and safety protocols.

Synthesis Pathways:
The synthesis of 3-Bromo-4-Fluorophenol commonly involves electrophilic aromatic substitution reactions. A primary route is the regioselective bromination of 4-fluorophenol. This process typically utilizes brominating agents like N-bromosuccinimide (NBS) or elemental bromine in appropriate solvents, often at low temperatures to control selectivity and minimize unwanted byproducts. Advanced synthetic strategies may involve multi-step sequences starting from more accessible precursors, with a focus on achieving high yields and purity. Manufacturers like NINGBO INNO PHARMCHEM CO.,LTD. optimize these processes to deliver consistent product quality for industrial purchase.

Key Applications:
The significance of 3-Bromo-4-Fluorophenol lies in its broad utility as a chemical intermediate:

  • Pharmaceutical Intermediates: It serves as a crucial building block in the synthesis of various Active Pharmaceutical Ingredients (APIs). Its halogenated phenolic structure is incorporated into molecules designed for anti-inflammatory, analgesic, and antiviral therapeutic areas. For pharmaceutical companies, securing a reliable supplier for this intermediate is vital for drug development pipelines.
  • Agrochemical Intermediates: In the agrochemical sector, this compound is instrumental in creating new herbicides, pesticides, and plant growth regulators. The strategic placement of bromine and fluorine can enhance efficacy and target specificity, contributing to more sustainable agricultural practices. Agrochemical manufacturers often look for competitive pricing and bulk availability from trusted suppliers.
  • Advanced Materials Science: 3-Bromo-4-Fluorophenol is also finding applications in materials science, particularly in the development of functional polymers and organic electronic materials. Its derivatives can be used in creating polymers with enhanced thermal stability or as precursors for hole-transport materials in OLEDs and solar cells. Researchers in this field benefit from access to high-purity materials for their experiments.
  • Specialty Organic Synthesis: The compound's versatile reactivity makes it an excellent starting material for complex organic synthesis projects, enabling the creation of intricate molecular architectures for research and development purposes.

Sourcing and Quality Assurance:
As a premier manufacturer and supplier of 3-Bromo-4-Fluorophenol, NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing high-purity products that meet the stringent demands of global industries. Our commitment to quality assurance, coupled with competitive pricing and reliable supply chain management, ensures that our clients receive the best possible value. We encourage R&D scientists and procurement managers to contact us to discuss their specific needs, obtain a quote, and explore bulk purchase options for this indispensable chemical intermediate.

In conclusion, 3-Bromo-4-Fluorophenol is a cornerstone intermediate that fuels innovation across multiple scientific and industrial sectors. Its unique properties and broad applicability underscore its importance in modern chemical synthesis.