For scientists, researchers, and procurement specialists across various industries, a thorough understanding of chemical intermediates is key to successful project execution. 3-Fluoropyridine (CAS 372-47-4) is a prime example of such a compound, valued for its specific chemical structure and wide-ranging applications. This article provides an overview of its properties and primary use cases, highlighting its importance as a chemical building block.

Chemical and Physical Characteristics

3-Fluoropyridine is a heterocyclic organic compound with the molecular formula C5H4FN and a molecular weight of approximately 97.09 g/mol. It typically presents as a clear, colorless to pale yellow liquid. Key physical properties include:

  • Appearance: Colorless to light yellow liquid.
  • Purity: Commonly supplied with a purity of ≥99.0% (GC assay).
  • Boiling Point: Approximately 107-108 °C.
  • Density: Around 1.13 g/mL at 25 °C.
  • Flash Point: Reported around 56 °F (13 °C), indicating it is flammable and requires careful handling.
  • Refractive Index: Approximately 1.472.

These properties make 3-Fluoropyridine suitable for various chemical processes and storage conditions, provided appropriate safety measures are observed. Its stability under normal conditions and its specific reactivity profile are major advantages.

Key Applications

The versatility of 3-Fluoropyridine stems from its utility as an intermediate in synthesizing more complex molecules. Its primary applications are:

  1. Pharmaceutical Intermediates: It is widely used in the synthesis of Active Pharmaceutical Ingredients (APIs). The introduction of a fluorinated pyridine moiety can significantly influence a drug's pharmacokinetic properties, such as absorption, distribution, metabolism, and excretion (ADME), potentially leading to improved efficacy and reduced toxicity.
  2. Agrochemical Synthesis: In the agrochemical industry, 3-Fluoropyridine serves as a building block for novel pesticides, herbicides, and fungicides. The fluorine atom can enhance the biological activity and environmental stability of these agricultural chemicals.
  3. Organic Synthesis: Researchers utilize 3-Fluoropyridine in various organic reactions to create diverse heterocyclic compounds. Its participation in nucleophilic substitution and other functionalization reactions makes it a valuable tool for developing new materials and fine chemicals.

Sourcing Considerations

For businesses looking to purchase 3-Fluoropyridine, understanding its specifications and sourcing from reliable suppliers is critical. A reputable 3-Fluoropyridine manufacturer in China can provide the necessary quality assurance, competitive pricing, and consistent supply. Whether you are performing research or scaling up production, ensuring the purity and availability of this intermediate is paramount.

In conclusion, 3-Fluoropyridine (CAS 372-47-4) is a fundamental chemical intermediate with significant applications in driving innovation in pharmaceuticals, agrochemicals, and organic synthesis. Its distinct properties make it a valuable compound for researchers and industrial clients alike.