In the realm of organic synthesis, specific chemical intermediates stand out for their versatility and crucial role in constructing complex molecular architectures. 3-Iodobenzotrifluoride (CAS 401-81-0) is one such compound, valued for its unique combination of a trifluoromethyl group and an iodine substituent on a benzene ring. This article delves into its chemical properties and highlights its broad applications, particularly for R&D scientists and formulators looking to buy 3-Iodobenzotrifluoride.

Chemical Properties of 3-Iodobenzotrifluoride

3-Iodobenzotrifluoride, with the molecular formula C7H4F3I, is typically characterized as a light yellow liquid. Its key physical properties include:

  • Molecular Weight: 272.01 g/mol
  • Boiling Point: Approximately 82-83 °C at 25 mmHg.
  • Density: Around 1.887 g/mL at 25 °C.
  • Purity: Commonly available at 97% or 98% purity.
  • Reactivity: The iodine atom makes it susceptible to various metal-catalyzed cross-coupling reactions, while the trifluoromethyl group offers electronic and steric influence.

These properties make it a robust choice for chemical manufacturers and researchers seeking reliable trifluoromethyl organic compounds for sale.

Applications in Synthesis and Research

The presence of both the iodine and the trifluoromethyl group makes 3-Iodobenzotrifluoride an exceptionally useful building block in organic synthesis:

  • Cross-Coupling Reactions: It readily participates in palladium-catalyzed reactions like Suzuki, Heck, and Sonogashira couplings, allowing for the formation of new carbon-carbon bonds. This is fundamental in constructing complex organic molecules for pharmaceuticals and agrochemicals.
  • Pharmaceutical Intermediates: The trifluoromethyl group is known to improve the lipophilicity, metabolic stability, and binding affinity of drug candidates. Therefore, 3-Iodobenzotrifluoride is a critical precursor for many fluorinated pharmaceutical intermediates. Researchers often inquire about the CAS 401-81-0 supplier to secure this compound for drug discovery programs.
  • Agrochemicals: Similar to pharmaceuticals, the CF3 group can enhance the efficacy and environmental persistence of pesticides and herbicides. It is used in the synthesis of various agrochemical compounds.
  • Material Science: Its unique electronic properties can be exploited in the development of specialized materials, such as organic semiconductors or advanced polymers.

Sourcing 3-Iodobenzotrifluoride: Price and Availability

When sourcing this essential intermediate, it is important to consider both quality and cost. Leading manufacturers in China offer competitive 3-Iodobenzotrifluoride price points, making it an accessible reagent for extensive research. As a trusted 3-Iodobenzotrifluoride manufacturer China, we ensure that our product meets high purity standards, facilitating your synthesis projects. If you are looking to buy 3-Iodobenzotrifluoride online, partner with a supplier committed to excellence and reliability.

Understanding the properties and applications of 3-Iodobenzotrifluoride empowers chemists and procurement specialists to make informed decisions. For reliable access to this versatile building block, consider established suppliers who prioritize quality and customer service.