For chemists and material scientists, a thorough understanding of chemical intermediates is key to successful synthesis and product development. 3-Thiophenecarboxaldehyde (CAS 498-62-4) stands out as a significant fine chemical, valued for its distinct properties and diverse applications, particularly as a pharmaceutical intermediate. As a reputable manufacturer and supplier, we offer insights into this important compound.

3-Thiophenecarboxaldehyde is characterized by its physical state as a colorless to pale yellow liquid. Its molecular formula is C5H4OS, with a molecular weight of 112.15 g/mol. Key physical properties include a melting point of -30 °C and a boiling point typically around 194-196 °C, making it a stable liquid under standard laboratory conditions. The refractive index (n20/D) is approximately 1.583, and its density is about 1.28 g/mL at 25 °C. These characteristics are crucial for its handling, storage, and application in various chemical reactions.

The synthesis of 3-Thiophenecarboxaldehyde generally involves formylation reactions applied to thiophene derivatives. While specific industrial synthesis routes are often proprietary, common methods involve using reagents like phosphorus oxychloride and dimethylformamide (Vilsmeier-Haack reaction) on a thiophene precursor, or related electrophilic substitution reactions. The precise control over reaction conditions is essential to achieve high yields and the desired purity, typically exceeding 98% or 99% for most demanding applications, such as those in the pharmaceutical industry.

As a pharmaceutical intermediate, 3-Thiophenecarboxaldehyde serves as a fundamental building block for a wide array of drug molecules. Its aldehyde functionality allows for numerous condensation, oxidation, and reduction reactions, enabling the construction of complex heterocyclic systems common in medicinal chemistry. Beyond pharmaceuticals, it is also employed in the development of novel polymers and as a reagent in specific biological research contexts, further underscoring its versatility.

For professionals looking to procure 3-Thiophenecarboxaldehyde, understanding these properties and common synthesis approaches helps in evaluating potential suppliers. As a dedicated manufacturer, we ensure our product meets these critical specifications. We are committed to providing high-quality 3-Thiophenecarboxaldehyde at competitive prices, along with reliable supply and technical support. If you are seeking CAS 498-62-4 for your research or manufacturing needs, we encourage you to contact us for a quote and to discuss how we can best serve you.

In summary, 3-Thiophenecarboxaldehyde is a fine chemical intermediate with a well-defined set of properties that make it invaluable in pharmaceutical synthesis, polymer science, and biological studies. Understanding these aspects ensures informed sourcing decisions.