4-Bromochlorobenzene (CAS 106-39-8) is a fundamental organic compound widely used in various chemical industries, most notably as a key intermediate in the synthesis of pharmaceuticals and diagnostic reagents. Its molecular structure, C6H4BrCl, possesses a unique combination of halogen substituents that grants it specific reactivity, making it invaluable for complex organic transformations. This article provides an in-depth look at its synthesis, properties, and the importance of sourcing it reliably.

Synthesis Routes and Chemical Properties:
The synthesis of 4-Bromochlorobenzene typically involves halogenation reactions of benzene derivatives. Common methods can include the direct bromination of chlorobenzene under specific catalytic conditions, or vice versa, the chlorination of bromobenzene. Precise control over reaction conditions is crucial to ensure regioselectivity and achieve high purity. For instance, literature often details 4-Bromochlorobenzene synthesis procedures involving reagents like bromine or N-bromosuccinimide (NBS) in the presence of Lewis acid catalysts, or chlorination using chlorine gas or N-chlorosuccinimide (NCS).

The compound exhibits distinct physical and chemical properties:

  • Appearance: Typically a white to almost white crystalline powder.
  • Melting Point: In the range of 64-67 °C, indicating it is a solid at room temperature.
  • Boiling Point: Approximately 196 °C.
  • Solubility: It is sparingly soluble in water (0.045 g/L) but generally soluble in common organic solvents.
  • Molecular Weight: 191.45 g/mol.

These properties are critical for chemists when planning reactions and purification steps. Understanding its chemical reactivity, particularly the differential reactivity of the C-Br and C-Cl bonds, allows for selective synthetic manipulation.

Applications and Market Demand:
The primary demand for 4-Bromochlorobenzene stems from its role as an intermediate in the production of Active Pharmaceutical Ingredients (APIs) and in the formulation of diagnostic reagents. Its structure allows for its incorporation into a vast number of complex organic molecules through various coupling reactions. This makes it a sought-after chemical for research and development as well as for large-scale manufacturing. Consequently, reliable sourcing from competent 4-Bromochlorobenzene manufacturers is essential.

Sourcing and Supply Chain Considerations:
When looking to buy 4-Bromochlorobenzene, buyers prioritize quality, consistency, and competitive pricing. Working with a reputable 4-Bromochlorobenzene supplier, particularly one with strong manufacturing capabilities in regions like China, can offer significant advantages. It is important to ensure the supplier provides detailed product specifications, Certificates of Analysis (COA), and adheres to strict quality control measures. Understanding the price of 4-Bromochlorobenzene involves considering purity, order volume, and market dynamics. Engaging directly with a manufacturer can streamline the procurement process and offer better value.

NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to being a premier source for high-quality 4-Bromochlorobenzene. We offer reliable supply, excellent product specifications, and responsive customer service to meet the demands of various industries. Contact us today to inquire about our products and how we can support your chemical sourcing needs.