In the realm of chemical manufacturing, specific compounds serve as foundational elements for producing more complex and valuable substances. 4-Cyanobenzyl Bromide, identified by its CAS number 17201-43-3, is one such crucial intermediate, primarily recognized for its role in the synthesis of the anti-diabetic drug, Alogliptin. For R&D chemists and production managers, a thorough understanding of this compound's properties and applications is essential for efficient sourcing and utilization.

Chemical Profile and Key Properties

4-Cyanobenzyl Bromide is characterized by its molecular formula C8H6BrN and a molecular weight of approximately 196.04. Physically, it typically presents as an off-white to pale yellow crystalline powder. Its chemical structure incorporates both a nitrile group (-CN) and a benzylic bromide group (-CH2Br), making it a reactive and versatile reagent in organic synthesis. The presence of the bromide atom makes it an excellent electrophile, readily participating in nucleophilic substitution reactions. Its physical properties, such as a melting point typically in the range of 70-74°C, are important for handling and storage considerations. Manufacturers often specify purity levels exceeding 99.0% (HPLC) to ensure its suitability for demanding applications like pharmaceutical synthesis.

Primary Application: Alogliptin Synthesis

The most significant application of 4-Cyanobenzyl Bromide is its use as a key intermediate in the manufacturing process of Alogliptin. Alogliptin is a DPP-4 inhibitor used to manage type 2 diabetes by improving glycemic control. The synthesis route involves using 4-Cyanobenzyl Bromide to build specific parts of the Alogliptin molecule. The demand for high-purity 4-Cyanobenzyl Bromide for this purpose drives its market, making it a sought-after chemical for pharmaceutical companies and contract manufacturing organizations (CMOs).

Beyond Alogliptin: Other Synthetic Uses

While Alogliptin synthesis is its primary driver, 4-Cyanobenzyl Bromide can also serve as a valuable building block in other areas of organic synthesis. Its dual functionality allows it to be incorporated into a variety of complex organic molecules. Researchers and chemists looking for specific functionalization of aromatic rings or the introduction of a cyanobenzyl moiety can find this compound useful. For those seeking to buy 4-cyanobenzyl bromide for general organic synthesis or specialized research, sourcing from a reliable 4-cyanobenzyl bromide supplier who can provide consistent quality and technical data is paramount.

Procurement Considerations

When procuring 4-Cyanobenzyl Bromide, prospective buyers should always inquire about the 4-cyanobenzyl bromide price and availability. Working with a reputable 4-cyanobenzyl bromide manufacturer ensures that the product meets the necessary specifications. Understanding the packaging (e.g., in drums or bags suitable for chemical transport) and storage recommendations (cool, dry place, protected from light and moisture) is also important for maintaining product integrity. If you are in need of this essential chemical intermediate for your research or manufacturing, reaching out to a trusted supplier for a quote on 4-cyanobenzyl bromide for sale is the next logical step.