In the vast landscape of organic chemistry, certain molecules serve as indispensable cornerstones for creating a myriad of valuable compounds. 4-Cyanobenzyl Bromide, identified by its CAS registry number 17201-43-3, is one such fundamental building block, highly prized for its versatility and reactive nature. This article delves into the essential aspects of this compound, including its key chemical properties, common synthesis methods, and the strategic considerations for sourcing it, particularly from leading manufacturers in China. For purchasing managers and R&D scientists, a thorough understanding of these facets is crucial for efficient procurement and successful project execution.

Chemically, 4-Cyanobenzyl Bromide (C8H6BrN) is characterized by a molecular weight of approximately 196.04 g/mol. It typically presents as a white crystalline powder with a melting point in the range of 115-117°C. The compound's structure features a benzene ring substituted with a nitrile (-CN) group at the para position and a bromomethyl (-CH2Br) group. This combination of functional groups dictates its reactivity, making the benzylic bromide highly susceptible to nucleophilic substitution reactions. Its solubility in common organic solvents like chloroform and methanol, contrasted with its insolubility in water, are important considerations for handling and reaction planning. Purity levels of 99% or higher are commonly sought after by end-users to ensure optimal performance in downstream applications.

The synthesis of 4-Cyanobenzyl Bromide typically begins with precursors such as p-tolunitrile or 4-(hydroxymethyl)benzonitrile. Common synthetic routes involve bromination reactions, often employing reagents like phosphorus pentoxide and potassium bromide in ethanol, or utilizing N-bromosuccinimide (NBS) under radical conditions. These methods, while established, require careful control of reaction parameters to achieve high yields and purity. For industrial-scale production, optimizing these synthesis pathways for efficiency, cost-effectiveness, and environmental sustainability is a key focus for manufacturers.

When it comes to sourcing 4-Cyanobenzyl Bromide, China has emerged as a dominant global manufacturing hub. Numerous Chinese chemical companies specialize in the production of fine chemicals and intermediates, including CAS 17201-43-3. For purchasing managers, identifying a reliable 4-cyanobenzyl bromide manufacturer is critical. This involves evaluating factors such as production capacity, quality control systems (e.g., ISO certifications), adherence to international standards, and competitive 4-cyanobenzyl bromide price offerings. Engaging directly with manufacturers or their authorized distributors can provide the best access to product information, quotations, and reliable supply chains.

The demand for 4-Cyanobenzyl Bromide is significantly driven by its application as a key intermediate in the pharmaceutical industry, particularly in the synthesis of Alogliptin. However, its utility extends to agrochemical development and various organic synthesis projects. Therefore, a robust understanding of its properties, synthesis, and the sourcing landscape, particularly the capabilities of Chinese 4-cyanobenzyl bromide suppliers, is essential for any organization looking to leverage this versatile chemical intermediate. By making informed procurement decisions, businesses can ensure a stable supply of high-quality material, facilitating their research, development, and manufacturing endeavors.