In the intricate world of pharmaceutical manufacturing, the quality and availability of chemical intermediates are paramount. One such compound gaining significant attention is 4-Hydroxy-3-nitrobenzonitrile, identified by its CAS number 3272-08-0. This versatile yellow powder serves as a critical building block, primarily in the synthesis of Febuxostat, a widely prescribed medication for managing gout and hyperuricemia. For procurement managers and R&D scientists, understanding the properties and sourcing options for this intermediate is crucial for ensuring efficient production and cost-effectiveness.

4-Hydroxy-3-nitrobenzonitrile, also known by synonyms such as 2-Nitro-4-cyanophenol, is characterized by its molecular formula C7H4N2O3 and a molecular weight of 164.118 g/mol. Its physical attributes include a density of approximately 1.5±0.1 g/cm³, a melting point of 146-148 °C, and a flash point of 128.5±24.6 °C, indicating moderate thermal stability. Crucially for pharmaceutical applications, it is typically supplied with an assay purity of ≥98.0%. This high purity level is essential for minimizing impurities in the final active pharmaceutical ingredient (API).

The primary industrial significance of 4-Hydroxy-3-nitrobenzonitrile lies in its role as a precursor to Febuxostat. The synthesis of Febuxostat involves several steps where this nitrobenzonitrile derivative provides the necessary chemical structure and functional groups. As the global demand for effective gout treatments like Febuxostat continues to grow, the reliable supply of high-quality 4-Hydroxy-3-nitrobenzonitrile from manufacturers becomes increasingly important. Companies seeking to buy this intermediate often look for established suppliers who can guarantee consistent quality and competitive Febuxostat intermediate price.

When sourcing this chemical, it is advisable to partner with reputable manufacturers and suppliers, particularly those based in China, which is a major hub for fine chemical production. A reliable 4-Hydroxy-3-nitrobenzonitrile manufacturer in China can offer not only cost advantages but also adhere to international quality standards. Procurement managers should inquire about packaging options, typically available in 25 kg drums, and ensure appropriate storage conditions are maintained to preserve the compound's integrity. For those looking to purchase 2-nitro-4-cyanophenol for their research and development projects, ensuring a steady supply chain is key to uninterrupted progress.

In summary, 4-Hydroxy-3-nitrobenzonitrile is more than just a chemical compound; it is a vital link in the pharmaceutical supply chain. Its consistent availability and high purity are critical for the production of essential medicines. By understanding its properties and engaging with trusted suppliers, pharmaceutical companies can secure the materials needed to meet market demands and drive innovation in healthcare.