In the complex world of pharmaceutical manufacturing, the quality and availability of key intermediates are paramount. One such vital compound is 4-Nitroisoindolin-1-one, a critical precursor in the synthesis of Lenalidomide. Understanding its properties and sourcing it reliably are crucial for any company involved in the production of this important API.

What is 4-Nitroisoindolin-1-one?

4-Nitroisoindolin-1-one, with CAS number 366452-97-3, is an organic compound widely recognized for its role as a pharmaceutical intermediate. Its chemical structure makes it an ideal building block for more complex molecules. It typically appears as a white to light yellow powder, indicating its purity and physical state. The assay is generally specified at ≥98.0%, a standard that pharmaceutical manufacturers rely on for consistent synthesis outcomes.

The Importance in Lenalidomide Synthesis

Lenalidomide is a widely used immunomodulatory drug, critical in treating various cancers, including multiple myeloma and myelodysplastic syndromes. The synthesis of Lenalidomide involves several intricate steps, and 4-Nitroisoindolin-1-one is a fundamental starting material in this process. Its specific chemical structure is tailored to undergo subsequent reactions that ultimately lead to the formation of the Lenalidomide molecule. The purity of 4-Nitroisoindolin-1-one directly impacts the yield and purity of the final Lenalidomide product, making its quality a non-negotiable factor for pharmaceutical producers.

Sourcing and Manufacturing Considerations

For pharmaceutical companies, securing a consistent and high-quality supply of 4-Nitroisoindolin-1-one is essential. This involves partnering with reputable manufacturers and suppliers. When looking to buy 4-Nitroisoindolin-1-one, especially in bulk for commercial production, it is imperative to consider factors such as product purity, adherence to specifications, reliable manufacturing capacity, and competitive pricing. Suppliers often offer it in standard packaging, such as 25 kg drums, to facilitate large-scale operations.

Engaging with a 4-Nitroisoindolin-1-one manufacturer in China, like NINGBO INNO PHARMCHEM CO.,LTD., can provide a strategic advantage. China has a robust chemical manufacturing sector, known for producing high-quality intermediates at competitive prices. A reliable supplier not only provides the chemical but also offers essential technical support and documentation that may be required for regulatory submissions.

Choosing the Right Supplier

When evaluating potential suppliers for 4-Nitroisoindolin-1-one, prospective buyers should inquire about their production capabilities, quality control processes, and ability to provide a stable supply chain. Understanding the 4-Nitroisoindolin-1-one price in the market is also important, but it should always be balanced against the assurance of quality and reliability. For those seeking to source this critical component, focusing on manufacturers with a proven track record in producing pharmaceutical intermediates is the most prudent approach. This ensures that your Lenalidomide manufacturing process is supported by the highest quality raw materials, ultimately contributing to the efficacy and safety of the final drug product.