5-Bromo-2-chloropyridine (CAS 53939-30-3) is a heterocyclic organic compound that has garnered significant attention in the chemical industry due to its utility as a versatile intermediate. Its chemical formula, C5H3BrClN, and molecular weight of 192.44 g/mol hint at its potential for diverse reactions. Understanding its properties, how it's synthesized, and where to reliably source it are crucial for researchers and procurement specialists alike.

Physically, 5-Bromo-2-chloropyridine typically presents as an off-white to yellow powder, with a melting point range often cited between 65-69°C. This solid form makes it relatively easy to handle and measure for laboratory and industrial processes. Its chemical properties are defined by the presence of both bromine and chlorine atoms on the pyridine ring, enabling selective reactions. For instance, the bromine atom can be a good leaving group in various cross-coupling reactions (like Suzuki, Sonogashira, or Buchwald-Hartwig couplings), while the chlorine atom can also be substituted under specific conditions. This dual reactivity makes it a highly adaptable building block.

The synthesis of 5-Bromo-2-chloropyridine often involves the selective halogenation of pyridine derivatives. Patent literature and scientific publications describe various methods, often starting from 2-hydroxypyrimidine or similar precursors. One-step synthesis methods are also being developed to improve efficiency and reduce waste. For example, patent CN114591250A describes a one-step synthesis method utilizing 2-hydroxypyrimidine, hydrobromic acid, hydrogen peroxide, and phosphorus oxychloride, aiming to enhance raw material utilization and production efficiency. While complex synthesis routes exist, the focus for industrial application is often on cost-effectiveness and scalability.

The applications of 5-Bromo-2-chloropyridine are widespread. In the pharmaceutical industry, it serves as a key intermediate for active pharmaceutical ingredients (APIs) targeting a range of conditions, from inflammation to infections. Its incorporation into drug molecules can enhance their binding affinity or metabolic stability. In the agrochemical sector, it’s employed in the synthesis of pesticides and herbicides, contributing to crop protection. Furthermore, its unique structure finds use in material science, for example, in the development of specialized polymers or electronic materials where its halogenated aromatic system can impart specific properties.

For businesses looking to procure 5-Bromo-2-chloropyridine, identifying a dependable supplier is paramount. Searching for 'buy 5-bromo-2-chloropyridine CAS 53939-30-3' or '5-bromo-2-chloropyridine price' will yield numerous results. However, it's important to consider factors beyond just the price. A reputable manufacturer will offer products with guaranteed purity (often above 99%), provide detailed product specifications, safety data sheets (SDS), and certificates of analysis (COA). Sourcing from established chemical suppliers, particularly those with a strong presence as a manufacturer in China, can ensure both quality and competitive pricing, facilitating your research and production needs.