For professionals engaged in organic synthesis, a deep understanding of key intermediates is crucial for successful project execution. 5-Chloro-2-iodopyridine (CAS: 244221-57-6) is one such compound that has garnered significant attention due to its versatile chemical reactivity. As a dedicated manufacturer and supplier of fine chemical intermediates, we aim to equip our B2B customers with the knowledge needed to confidently source and utilize this valuable compound. This article outlines its properties, synthesis applications, and best practices for procurement.

Chemical Profile and Properties of 5-Chloro-2-iodopyridine

5-Chloro-2-iodopyridine is characterized by its molecular formula C5H3ClIN and a molecular weight of 239.44. From a physical standpoint, it is typically described as a white powder, with a melting point range often specified between 85-92°C or higher, indicating it is a solid at room temperature. Its density is around 2.052 g/cm³, and it exhibits limited solubility in water but is generally soluble in common organic solvents. Crucially, its purity is often guaranteed at ≥98.0%, making it suitable for demanding synthetic applications. The presence of both a chlorine and an iodine atom on the pyridine ring provides distinct reactive sites, enabling selective functionalization.

Synthesis Applications and Reaction Versatility

The primary utility of 5-Chloro-2-iodopyridine lies in its role as an intermediate in organic synthesis. Its halogen atoms, particularly the iodine, are excellent leaving groups, making it highly reactive in metal-catalyzed cross-coupling reactions. This includes:

  • Carbon-Carbon Bond Formation: Reactions like the Suzuki-Miyaura coupling (with boronic acids), Heck reaction (with alkenes), and Sonogashira coupling (with alkynes) readily occur at the iodine position, allowing for the attachment of various organic fragments.
  • Carbon-Heteroatom Bond Formation: It can also participate in nucleophilic aromatic substitution reactions or Buchwald-Hartwig amination to form C-N bonds.

These synthetic capabilities are vital for creating complex molecules used in pharmaceuticals, agrochemicals, and materials science. For instance, it has been employed in the synthesis of inhibitors for enzymes like mPGES-1 and in the creation of novel anti-tumor agents. When you buy 5-Chloro-2-iodopyridine, you are acquiring a tool that significantly broadens the scope of achievable molecular structures.

Choosing a Reliable Supplier in China

For businesses seeking to procure 5-Chloro-2-iodopyridine, partnering with a trustworthy manufacturer in China offers distinct advantages. Direct sourcing from established producers ensures quality consistency, competitive pricing, and reliable delivery. We, as a manufacturer, adhere to stringent quality control standards, ensuring that our 5-Chloro-2-iodopyridine consistently meets the ≥98.0% purity requirement. Our supply chain is robust, designed to meet the demands of both small-scale R&D projects and large-scale commercial production. When you request a quote, you can expect transparency regarding pricing, lead times, and product specifications.

In summary, 5-Chloro-2-iodopyridine is a powerful intermediate for any chemist involved in advanced organic synthesis. By understanding its properties and applications, and by choosing a reputable manufacturer, you can effectively integrate this compound into your workflow, driving innovation in your respective fields.