5-tert-Butyl-m-xylene (CAS 98-19-1), also known as 1-tert-butyl-3,5-dimethylbenzene, is a foundational organic intermediate with significant utility across various chemical industries. Its unique molecular structure, featuring a tert-butyl group and two methyl groups on a benzene ring, dictates its reactivity and makes it a valuable precursor for a range of complex molecules. At NINGBO INNO PHARMCHEM CO.,LTD., we specialize in providing high-quality 5-tert-butyl-m-xylene to meet diverse research and industrial needs.

The synthesis of 5-tert-butyl-m-xylene predominantly involves Friedel-Crafts alkylation reactions. A common and efficient method utilizes the alkylation of m-xylene with tert-butanol in the presence of acid catalysts. Advanced catalysts, such as the mesoporous superacid UDCaT-5, have been developed to offer high selectivity and conversion rates, often under milder, more environmentally friendly conditions compared to traditional Lewis acid catalysts. This focus on improved synthesis methodologies ensures a cleaner and more cost-effective supply chain.

The chemical reactivity of 5-tert-butyl-m-xylene is primarily governed by the activated aromatic ring, making it susceptible to electrophilic aromatic substitution reactions. For instance, nitration of the compound can lead to the formation of musk xylene, historically used in fragrances, or can serve as an intermediate step for other chemical syntheses. Oxidation reactions typically target the methyl groups, leading to carboxylic acid derivatives like 5-tert-butylisophthalic acid, which is a valuable monomer for polymer production. Understanding these reaction pathways is crucial for optimizing downstream applications.

One of the most significant applications of 5-tert-butyl-m-xylene is its role as a key intermediate in the synthesis of Xylometazoline, a widely used pharmaceutical agent for nasal decongestion. The multi-step synthesis involves steps such as chloromethylation and cyanation, highlighting the importance of high-purity starting materials. Beyond pharmaceuticals, it finds utility as a building block in agrochemical synthesis and in material science, showcasing its versatility.

NINGBO INNO PHARMCHEM CO.,LTD. is committed to supplying 5-tert-butyl-m-xylene with exceptional purity and consistency. Our stringent quality control measures ensure that our product meets the demanding specifications required by the pharmaceutical and specialty chemical industries. By choosing us as your supplier, you gain access to a reliable source of this essential chemical intermediate, backed by expert technical support and a dedication to customer satisfaction.

For inquiries or to request a quote for 5-tert-butyl-m-xylene, please contact NINGBO INNO PHARMCHEM CO.,LTD. We are your trusted partner for high-quality chemical intermediates.