For chemists and procurement specialists in the pharmaceutical and fine chemical industries, a thorough understanding of key intermediates is fundamental. This article explores 6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole (CAS: 1231930-33-8), detailing its properties, synthesis, and critical applications. As a vital building block, particularly for the development of advanced pharmaceuticals, knowledge of this compound is indispensable for those looking to buy or utilize it.

The chemical structure of 6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole is characterized by a benzo[d]imidazole core, functionalized with a bromine atom at the 6-position, a fluorine atom at the 4-position, an isopropyl group attached to the nitrogen at the 1-position, and a methyl group at the 2-position. Its molecular formula is C11H12BrFN2, and it has a molecular weight of approximately 271.13 g/mol. Typically, it presents as an off-white to yellow solid, a key physical characteristic that aids in its identification and quality assessment. The melting point, around 353.4±22.0 °C (predicted), further defines its solid state at room temperature.

The synthesis of this intermediate, often starting from precursors like N-(4-bromo-2,6-difluorophenyl)-N'-isopropylacetamidine, involves precise chemical reactions under controlled conditions. Manufacturers employ sophisticated techniques to ensure high purity, commonly exceeding 97% as determined by HPLC. This high purity is critical for its primary application: serving as a key intermediate in the synthesis of Abemaciclib, a targeted therapy for breast cancer. Its specific structural features are designed to facilitate subsequent synthetic steps, contributing directly to the efficacy of the final drug product.

Beyond its role in Abemaciclib production, 6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole is also valuable in broader medicinal chemistry research. As a versatile heterocyclic building block, it can be utilized in the exploration of new drug candidates across various therapeutic areas. Researchers seeking to synthesize novel compounds or optimize existing structures may find this intermediate to be a valuable starting material. For such purposes, it's crucial to purchase from reliable suppliers who can offer consistent quality and availability.

Procurement professionals looking to buy this compound will find that Chinese manufacturers often offer competitive pricing and robust supply capabilities. When evaluating potential suppliers, consider their technical expertise, adherence to quality standards, and capacity for scale-up. Engaging with manufacturers who provide detailed product specifications, safety data sheets (SDS), and timely customer support is highly recommended. A free sample can be invaluable for initial research and development stages before committing to larger purchase volumes. We are a leading manufacturer committed to providing high-quality intermediates for your research and production needs.

In summary, understanding the chemical properties, synthesis, and applications of 6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole is essential for its effective utilization in pharmaceutical R&D and manufacturing. As a specialized manufacturer, we are dedicated to supplying this critical intermediate with the purity and reliability you need. Contact us to discuss your requirements and to secure your supply.