For researchers and product formulators delving into advanced chemical synthesis, a thorough understanding of key intermediates is essential. 6-Chloroquinazoline-2,4(1H,3H)-dione, identified by CAS number 1640-60-4, stands out as a valuable heterocyclic compound with significant utility. This article aims to provide an in-depth look at its properties and applications, guiding scientists in its effective utilization.

Chemically, 6-Chloroquinazoline-2,4(1H,3H)-dione (C8H5ClN2O2) presents as a white to off-white solid with a high melting point, typically around 360°C in acetic acid. Its molecular weight is approximately 196.59 g/mol, and it possesses a density of around 1.475 g/cm³. These physical characteristics are important for handling, storage, and reaction planning. The compound's structure, featuring a quinazoline core with a chlorine substituent and two carbonyl groups, makes it a reactive intermediate for various chemical transformations.

The synthesis of 6-Chloroquinazoline-2,4(1H,3H)-dione can be achieved through several routes, often involving the cyclization of substituted aromatic precursors. For example, reactions starting from 2-amino-5-chlorobenzonitrile under specific conditions, such as with carbon dioxide in the presence of a catalyst and solvent like DMSO, can yield the desired product. Manufacturers offering this chemical typically adhere to stringent quality control measures to ensure high purity, often exceeding 97%, which is critical for successful downstream synthesis.

The primary application of 6-Chloroquinazoline-2,4(1H,3H)-dione lies in its role as a pharmaceutical intermediate. Its structure provides a scaffold that can be modified to synthesize a wide array of biologically active compounds. Researchers use it in the development of novel drug candidates, exploring its potential in various therapeutic areas. Beyond pharmaceuticals, it also finds application in general organic synthesis and the creation of fine chemicals, where its specific reactivity profile is leveraged.

When considering the purchase of 6-Chloroquinazoline-2,4(1H,3H)-dione, it is advisable to seek out reputable suppliers who can provide detailed technical documentation, including Safety Data Sheets (SDS) and Certificates of Analysis (CoA). Understanding the safe handling procedures and potential hazards associated with the chemical is crucial for laboratory and production safety. As a chemical supplier from China, we are committed to delivering high-quality materials to support your research and manufacturing needs.