6-Nitrochroman-4-one, identified by its CAS number 68043-53-8, is a chemical compound that has garnered significant attention in the fields of pharmaceutical intermediates and advanced organic synthesis. Understanding its core properties, typical synthesis routes, and reliable sourcing channels is vital for researchers and procurement specialists looking to utilize this versatile building block.

Chemically, 6-Nitrochroman-4-one is characterized by its chroman ring system substituted with a nitro group at the 6th position and a ketone at the 4th position. This structure imparts unique reactivity, making it an attractive starting material for various chemical transformations. Its physical appearance is often described as a pale yellow crystalline solid, with a reported melting point range of 116-119°C. These specifications are crucial for ensuring the quality and suitability of the compound for specific research applications.

The synthesis of 6-Nitrochroman-4-one typically involves the nitration of chroman-4-one. This process requires careful control of reaction conditions, including temperature and the choice of nitrating agents, to achieve high yields and purity. For instance, using a mixture of concentrated sulfuric and nitric acids at low temperatures is a common method. The efficiency and safety of these synthetic routes are primary concerns for chemical manufacturers.

For organizations looking to buy 6-Nitrochroman-4-one, identifying a reputable supplier is paramount. Key considerations include the manufacturer's adherence to quality standards, their capacity for production, and the transparency of their documentation, such as Certificates of Analysis (CoA) and Safety Data Sheets (SDS). Companies specializing in pharmaceutical intermediates and fine chemicals, particularly those based in China like NINGBO INNO PHARMCHEM CO.,LTD., are often primary sources for this compound. Requesting a quote from multiple suppliers can help in securing competitive pricing and ensuring consistent supply.

The utility of 6-Nitrochroman-4-one extends to its role as a precursor in the synthesis of biologically active molecules and in the development of fluorescent probes and other advanced materials. Its strategic placement within synthetic pathways allows for the introduction of diverse functional groups, leading to a wide array of derivatives with potential therapeutic or material properties. Therefore, understanding its chemical behavior and availability is critical for research and development planning.

In conclusion, 6-Nitrochroman-4-one is a compound of considerable scientific and industrial interest. By understanding its properties, synthesis pathways, and the importance of sourcing from reliable manufacturers, researchers can effectively leverage this intermediate to drive their projects forward. Direct inquiries to known chemical suppliers for pricing and sample availability are recommended for seamless procurement.