In the vast landscape of industrial chemicals, Acetyl chloride (CAS 75-36-5) stands out as a highly reactive and versatile organic intermediate. Its unique chemical properties make it indispensable in a range of applications, particularly in the synthesis of pharmaceuticals, agrochemicals, and fine chemicals. For professionals seeking to understand or procure this compound, a clear grasp of its characteristics, uses, and the best strategies for sourcing is essential. This article serves as a comprehensive guide to Acetyl chloride for industrial buyers.

Acetyl chloride, with the chemical formula CH3COCl and identified by CAS number 75-36-5, is a colorless liquid that readily fumes in moist air, releasing hydrochloric acid and acetic acid. This reactivity is attributed to the highly electrophilic carbonyl carbon. Its physical state as a liquid at room temperature, coupled with its pungent, irritating odor, necessitates careful handling and storage in tightly sealed containers, away from moisture and ignition sources. The typical purity offered by manufacturers is 99% or higher, a critical specification that impacts reaction efficiency and product quality across various applications.

The primary utility of Acetyl chloride lies in its function as an acetylating agent. It readily reacts with alcohols to form esters and with amines to form amides. These reactions are fundamental in the synthesis of a wide array of organic compounds. In the pharmaceutical industry, it is a crucial precursor for synthesizing active pharmaceutical ingredients (APIs) like paracetamol, ibuprofen, and aspirin, as well as numerous intermediates. The consistent quality of Acetyl chloride directly influences the purity and efficacy of these vital medicines, making its procurement a critical step for pharmaceutical manufacturers.

Similarly, the agrochemical sector leverages Acetyl chloride in the production of active ingredients for pesticides, herbicides, and other crop protection agents. Its role in forming ester or amide linkages is common in the synthesis pathways of many agrochemicals, contributing to their effectiveness. For businesses in this sector, securing a reliable supply of high-purity Acetyl chloride at a competitive price is essential for operational efficiency and cost management. Exploring options for bulk Acetyl chloride purchase from established manufacturers is a common strategy.

Beyond pharmaceuticals and agrochemicals, Acetyl chloride is employed in the broader fine chemical industry for producing dyes, fragrances, and polymers. Its reactivity also makes it a valuable reagent in academic and industrial research laboratories for exploring new synthesis routes and developing novel compounds. When considering where to buy Acetyl chloride, buyers should prioritize suppliers who can provide comprehensive product information, including Safety Data Sheets (SDS) and Certificates of Analysis (CoA), ensuring compliance with safety regulations and quality standards.

For companies looking to source Acetyl chloride, understanding the supplier landscape is key. Many global manufacturers are based in China, offering competitive pricing and large-scale production capacities. Identifying a trustworthy CAS 75-36-5 supplier involves checking their quality certifications (e.g., ISO), customer reviews, and their ability to provide consistent, timely deliveries. A good supplier will also offer responsive customer service and technical support, assisting with any queries regarding product specifications or applications.

In summary, Acetyl chloride (CAS 75-36-5) is a cornerstone intermediate in chemical synthesis due to its powerful acetylating properties. Whether for pharmaceutical API production, agrochemical formulation, or fine chemical manufacturing, ensuring a high-purity, reliably sourced supply is paramount. By understanding its properties and following practical sourcing tips, buyers can confidently secure this essential chemical for their operations.