Benzylacetone, identified by its CAS number 2550-26-7, is a chemical compound of significant interest across various industrial sectors, including pharmaceuticals, fragrances, and fine chemical synthesis. Understanding its fundamental properties and common preparation routes is vital for researchers and procurement specialists looking to source this versatile molecule.

Physically, Benzylacetone presents as a clear, colorless to light yellow liquid. Its chemical formula is C10H12O, with a molecular weight of 148.202 g/mol. Key physical properties include a melting point of -13°C and a boiling point of approximately 233.5°C at 760 mmHg. The refractive index is around 1.504, and its density is approximately 1.0 g/cm³. Notably, it is practically insoluble in water but soluble in common organic solvents like ethanol and oils, characteristics that influence its handling and application in different formulations.

The compound's molecular structure, 4-phenyl-2-butanone, contributes to its characteristic sweet, floral, and sometimes described as honey-like aroma. This olfactory property makes it a valuable component in the fragrance industry, contributing to the scent profiles of perfumes, soaps, and cosmetics. In the flavor sector, it can impart mild, sweet notes to food products.

From a synthesis perspective, Benzylacetone can be prepared through several methods. A traditional route involves the condensation of benzaldehyde with acetone to form benzylidene acetone, followed by selective hydrogenation. Another approach described in literature involves the Friedel-Crafts acylation of toluene with acetic acid or related reactions. For industrial-scale production, manufacturers often optimize these processes for yield, purity, and cost-effectiveness. When considering purchasing Benzylacetone, inquiring about its synthesis route can provide valuable context regarding potential impurities and overall quality.

Beyond its use as an aroma chemical, Benzylacetone serves as a critical intermediate in organic synthesis, most prominently in the production of pharmaceuticals. For instance, it is a key precursor in the synthesis of Labetalol, a medication used to treat hypertension. This dual utility—as a fragrance ingredient and a pharmaceutical intermediate—underscores its importance in the chemical market. Researchers in drug discovery and development often require high-purity Benzylacetone to ensure the efficacy and safety of their final products.

Procurement managers seeking to buy Benzylacetone should pay close attention to purity levels, typically specified as an assay percentage (e.g., ≥99.0%). Reliable suppliers, often found in regions like China, provide detailed technical specifications, safety data sheets (SDS), and certificates of analysis to support purchasing decisions. Understanding these properties and preparation methods empowers buyers to select the most suitable Benzylacetone for their specific R&D or manufacturing requirements.