Boc-Arg(Pbf)-OH, identified by its CAS number 200124-22-7, stands as a pivotal compound within the realm of peptide chemistry and pharmaceutical research. As a protected derivative of L-arginine, it plays a crucial role in the synthesis of peptides, which are increasingly vital in therapeutic development and biochemical studies. Understanding its chemical properties and application scope is essential for scientists and procurement specialists aiming to leverage its potential.

The chemical structure of Boc-Arg(Pbf)-OH features two key protecting groups: the tert-butoxycarbonyl (Boc) group on the alpha-amino terminus and the 2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl (Pbf) group on the guanidino side chain of arginine. The Boc group is acid-labile, typically removed by trifluoroacetic acid (TFA) during peptide synthesis, allowing for the next amino acid coupling. The Pbf group, a bulky and electron-withdrawing sulfonamide, provides robust protection for the arginine side chain under various reaction conditions, including the acidic cleavage of the Boc group, and is itself typically removed by stronger acids like TFA or HF during final peptide deprotection.

The physical appearance of high-quality Boc-Arg(Pbf)-OH is generally a white to off-white solid or powder, a characteristic that is often a first indicator of its purity. Its molecular formula is C24H38N4O7S, with a molecular weight of approximately 526.65 g/mol. These specifications are critical for accurate stoichiometric calculations in synthesis protocols. For researchers looking to purchase Boc-Arg(Pbf)-OH, verifying these details along with the purity (commonly 99%) from a reliable Boc-Arg(Pbf)-OH supplier is standard practice.

In terms of applications, Boc-Arg(Pbf)-OH is indispensable in synthesizing peptides that incorporate arginine residues. Arginine is a semi-essential amino acid with a positively charged guanidinium side chain, which plays significant roles in protein structure, enzyme activity, and receptor binding. The correct incorporation of arginine, protected by groups like Pbf, is crucial for creating bioactive peptides, including hormones, neuropeptides, and peptide-based pharmaceuticals. Researchers seeking to buy pharmaceutical intermediates like Boc-Arg(Pbf)-OH often rely on specialized chemical companies that maintain high standards in production and quality assurance.

The competitive landscape for Boc-Arg(Pbf)-OH price means that strategic sourcing is key. By connecting with a reputable Boc-Arg(Pbf)-OH manufacturer in China, laboratories can often achieve significant cost savings without compromising on quality. Whether for academic research, early-stage drug discovery, or larger-scale peptide production, a consistent and reliable supply of this protected amino acid is foundational. Therefore, diligence in selecting a supplier that provides consistent quality, clear documentation, and responsive customer service is paramount for success in peptide chemistry endeavors.