For professionals in the pharmaceutical and chemical synthesis industries, having a firm grasp of key chemical intermediates is essential for driving innovation. Boc-L-4-Bromophenylalanine (CAS 62129-39-9) is one such compound, widely recognized for its critical role in both peptide synthesis and as a versatile pharmaceutical intermediate. This article outlines its applications and provides guidance on effective sourcing strategies, particularly for those looking to buy from reputable China-based suppliers.

Boc-L-4-Bromophenylalanine is an N-protected amino acid derivative. Its chemical structure features a tert-butoxycarbonyl (Boc) group protecting the amine terminus and a bromine atom substituted on the phenyl ring at the para position. This specific molecular architecture lends itself to several key applications. In peptide synthesis, the Boc group facilitates controlled chain elongation through solid-phase peptide synthesis (SPPS), a technique widely used for generating peptides for therapeutic and research purposes. The ability to remove the Boc group under specific acidic conditions allows for precise sequential addition of amino acids, ensuring the correct peptide sequence is built.

Beyond its use in peptide assembly, the bromine atom on Boc-L-4-Bromophenylalanine is a significant advantage for medicinal chemists. This halogen atom acts as a readily accessible site for further chemical modification. Through various cross-coupling reactions, such as Suzuki or Heck couplings, diverse functional groups or molecular scaffolds can be introduced onto the phenylalanine side chain. This capability is invaluable for creating novel drug candidates with tailored pharmacological properties, exploring structure-activity relationships (SAR), or synthesizing complex biomolecules.

As a pharmaceutical intermediate, Boc-L-4-Bromophenylalanine plays a crucial role in the synthesis of various active pharmaceutical ingredients (APIs). Its structural features allow for its incorporation into diverse synthetic pathways, leading to compounds with potential therapeutic applications. The L-chirality is critical for biological recognition and activity in many pharmaceutical compounds, making enantiomeric purity a vital specification when sourcing this chemical.

For procurement managers and researchers looking to buy Boc-L-4-Bromophenylalanine, partnering with a reliable manufacturer is key. Many high-quality chemical suppliers are based in China, offering competitive pricing and robust quality assurance. When sourcing, it is essential to look for suppliers that guarantee high purity (typically ≥98% by HPLC), provide detailed Certificates of Analysis (CoAs), and maintain a consistent supply chain. Requesting samples for initial testing is always recommended to ensure the material meets your specific project requirements. By securing a dependable source of high-quality Boc-L-4-Bromophenylalanine, organizations can significantly advance their R&D efforts and streamline their manufacturing processes.