For scientists and product developers working with complex organic molecules, a deep understanding of key chemical intermediates is fundamental. Boc-L-Isoleucine (CAS 13139-16-7) is a prime example of such an intermediate, widely utilized in peptide synthesis and pharmaceutical research. Its protected amino group and chiral center make it a versatile building block. As a leading fine chemical manufacturer based in China, we aim to provide clarity on the properties and synthesis pathways of Boc-L-Isoleucine, empowering our clients with essential knowledge.

Boc-L-Isoleucine, formally known as N-(tert-Butoxycarbonyl)-L-isoleucine, is derived from the naturally occurring amino acid L-isoleucine. The defining feature is the tert-butyloxycarbonyl (Boc) protecting group attached to the alpha-amino nitrogen. This group is stable under a variety of reaction conditions but can be selectively removed under acidic conditions, a property that is fundamental to its use in stepwise peptide synthesis. Chemically, it has the formula C11H21NO4 and a molecular weight of 231.29 g/mol. Physically, it typically presents as a white to off-white crystalline powder, with a melting point often cited in the range of 69-73 °C.

The synthesis of Boc-L-Isoleucine generally involves the reaction of L-isoleucine with di-tert-butyl dicarbonate (Boc2O) under basic conditions. This reaction is a standard method for introducing the Boc protecting group onto amino acids. For example, L-isoleucine can be dissolved in an aqueous base solution (like sodium hydroxide), and Boc2O, often dissolved in an organic solvent such as dioxane, is added. The mixture is stirred at room temperature until the reaction is complete, typically yielding Boc-L-Isoleucine in good yields (often exceeding 90%). Subsequent purification steps, such as extraction and crystallization, ensure the high purity required for downstream applications. Researchers can often find detailed synthesis protocols from reliable chemical suppliers or in scientific literature.

The properties of Boc-L-Isoleucine make it exceptionally useful in several areas. Its enhanced solubility in organic solvents compared to unprotected amino acids simplifies reaction procedures. The presence of the Boc group allows for controlled chain elongation in solid-phase peptide synthesis (SPPS) or solution-phase methods. Its significance in peptide synthesis is paramount, enabling the construction of peptides used in drug development, diagnostics, and academic research. Furthermore, it serves as a vital intermediate in the broader pharmaceutical and chemical synthesis sectors, contributing to the creation of diverse molecular architectures.

For professionals seeking to buy Boc-L-Isoleucine, understanding these chemical properties and synthesis methods aids in evaluating potential suppliers. When you source from a reputable Boc-L-Isoleucine manufacturer in China, you can expect consistent quality, often with a guaranteed purity of ≥99%. This is crucial for any application requiring high fidelity, such as the synthesis of therapeutic peptides. Engaging with a dedicated Boc-L-Isoleucine supplier ensures access to essential technical data, including detailed specifications and safety information.

Considering the cost-effectiveness of sourcing advanced intermediates, Chinese manufacturers often offer competitive Boc-L-Isoleucine prices, particularly for bulk quantities. This accessibility allows research laboratories and chemical companies to optimize their budgets without compromising on the quality of their raw materials. We are committed to providing our clients with not just high-quality products but also comprehensive support, including technical data and responsive customer service.

In conclusion, Boc-L-Isoleucine (CAS 13139-16-7) is a foundational chemical intermediate with well-defined properties and synthesis routes. Its protected nature and chemical characteristics make it indispensable for advanced synthetic chemistry, especially in the pharmaceutical and peptide sectors. By understanding its nature and sourcing from reliable Chinese manufacturers, researchers and formulators can ensure the success and efficiency of their projects. We invite you to inquire about our Boc-L-Isoleucine offerings and experience the quality and reliability we provide.