Boc-L-Leucine Hydrate (CAS 200936-87-4) is a significant chemical compound in the realm of organic synthesis, particularly favored for its role in peptide chemistry. As a derivative of the essential amino acid L-leucine, it features the tert-butyloxycarbonyl (Boc) protecting group on its alpha-amino terminus. This protection is critical for selective reactions and is widely employed by research scientists and chemical manufacturers. For those looking to buy high-quality material, understanding its properties is key.

Chemically, Boc-L-Leucine Hydrate is characterized by its molecular formula C11H21NO4·H2O and a molecular weight of approximately 249.3 g/mol. It typically appears as a white powder, with a melting point often cited between 80-90 °C. The hydrate form indicates the presence of a water molecule, which is important for its stability and handling characteristics. Its optical rotation, often measured as [α]D20 = -25 ± 2 º (C=2 in AcOH), confirms its L-chirality, a vital attribute for stereoselective synthesis in pharmaceutical and biochemical research.

The primary application of Boc-L-Leucine Hydrate lies in peptide synthesis. In Solid Phase Peptide Synthesis (SPPS) and solution-phase methods, the Boc group serves to transiently block the amino group of leucine. This allows for controlled, sequential addition of amino acids to build peptide chains of defined sequences. The Boc group is readily removed under mild acidic conditions (e.g., using trifluoroacetic acid, TFA), without damaging the growing peptide chain or other sensitive functional groups. This makes it an efficient and reliable protecting group strategy. Researchers often seek competitive pricing for this intermediate when planning multi-step syntheses.

Beyond peptide synthesis, Boc-L-Leucine Hydrate is a valuable building block in broader organic synthesis. Its chiral center and functional groups make it suitable for constructing complex organic molecules, including active pharmaceutical ingredients (APIs), specialty chemicals, and agrochemicals. The ability to incorporate a leucine residue with controlled stereochemistry is beneficial for creating molecules with specific biological activities. Chemical companies often list this as a core product, and sourcing it from a reputable manufacturer is essential for ensuring yield and purity.

When sourcing Boc-L-Leucine Hydrate, it is important to consider the supplier's capabilities and location. A reliable supplier in China, for instance, can offer competitive advantages in terms of cost and scale. These manufacturers are equipped to produce the compound in various quantities, from laboratory-scale research to industrial bulk orders, ensuring that the needs of diverse projects are met. Engaging with such suppliers for a quote facilitates efficient procurement.

In summary, Boc-L-Leucine Hydrate is a versatile and essential chemical intermediate. Its well-defined properties, particularly the protective Boc group and its chirality, make it a preferred choice for peptide synthesis and various organic chemistry applications. Understanding these characteristics and sourcing from reliable manufacturers is key for researchers aiming to achieve successful and cost-effective synthesis outcomes.