For chemists and biochemists engaged in peptide synthesis and organic research, understanding the properties and handling of key intermediates like BOC-L-Serine (CAS: 3262-72-4) is fundamental to achieving successful experimental outcomes. This protected amino acid derivative is a cornerstone in many synthetic pathways, and sourcing it from a quality manufacturer is key.

BOC-L-Serine, appearing as a fine white powder, is chemically known as N-(tert-Butoxycarbonyl)-L-serine. Its structure, C8H15NO5, with a molecular weight of 205.21 g/mol, includes the essential L-serine backbone protected by the BOC group on its alpha-amino terminus. This protection strategy is vital because it allows selective reactions at other functional groups, particularly the side-chain hydroxyl of serine or the carboxyl group, without interference from the amine. During peptide synthesis, the BOC group is typically removed under acidic conditions, typically using trifluoroacetic acid (TFA), to reveal the amine for subsequent peptide bond formation.

The synthesis of BOC-L-Serine commonly involves the reaction of L-serine with di-tert-butyl dicarbonate (Boc anhydride) in the presence of a base. Careful control of reaction conditions ensures high yield and purity, resulting in a product suitable for demanding applications. Researchers often procure BOC-L-Serine to utilize it as a starting material for the synthesis of various alpha-amino acids via the beta-lactone intermediate, a crucial step for creating stereochemically pure compounds.

The applications of BOC-L-Serine are diverse, spanning from fundamental research in biochemistry and molecular biology to applied fields such as drug discovery and material science. In peptide synthesis, it ensures the accurate incorporation of serine residues, which are crucial for protein folding, enzymatic activity, and receptor binding. Its hydroxyl group also makes it a versatile intermediate for creating modified amino acids or conjugating peptides to other molecules.

For scientists and procurement specialists looking to buy BOC-L-Serine, understanding the importance of purity and supplier reliability cannot be overstated. We, as a dedicated manufacturer and supplier, offer high-quality BOC-L-Serine that meets stringent purity standards. We provide comprehensive product information and competitive pricing, ensuring that you receive a reliable intermediate for your research and development needs. Our goal is to facilitate your scientific progress by making essential chemical building blocks readily accessible. Contact us to inquire about purchasing options and experience the quality and service we provide.