Understanding Butyl p-Toluenesulfonate (CAS 778-28-9): Properties and Synthesis Applications
For researchers and product formulators in the chemical and pharmaceutical industries, a deep understanding of key chemical intermediates is vital for successful synthesis and product development. Butyl p-Toluenesulfonate, identified by CAS number 778-28-9, is a compound that warrants close attention due to its versatility and utility in a range of synthetic applications.
Chemically, Butyl p-Toluenesulfonate (C11H16O3S) is an ester of p-toluenesulfonic acid and n-butanol. Its physical appearance is typically described as a colorless to light yellow transparent liquid. This classification is important for handling and storage protocols. The compound's molecular weight is approximately 228.31 g/mol. Its significance in chemical synthesis stems from the tosylate group (-OSO2C6H4CH3), which is an excellent leaving group, making it highly reactive in nucleophilic substitution reactions. This property allows it to be efficiently used as an alkylating agent.
The primary application of Butyl p-Toluenesulfonate is in the synthesis of pharmaceutical raw materials. It serves as a key intermediate in the construction of complex organic molecules that form the basis of many drugs. Beyond pharmaceuticals, its reactivity makes it a valuable tool for chemists in academia and industry engaged in various organic synthesis projects, including the creation of fine chemicals and specialized materials. Researchers looking to buy this compound for laboratory use or pilot-scale production will find that a minimum purity of 98.0% is standard from reputable manufacturers.
When considering the purchase of Butyl p-Toluenesulfonate, understanding its specifications is crucial. Typical parameters include assay (≥98.0%), moisture content (≤0.50%), and limits on related impurities. For scientists and engineers, knowing the physical properties such as density (around 1.12 g/mL) and boiling point (approximately 170-172°C at 10.0 mmHg) aids in process design and optimization. Companies looking for a reliable manufacturer or supplier of this intermediate often turn to specialized chemical providers who can ensure consistent product quality and competitive pricing, especially for bulk orders.
In summary, Butyl p-Toluenesulfonate is a highly functional intermediate with significant applications, particularly in pharmaceutical synthesis. Its well-defined chemical properties and reactivity make it a valuable asset for any chemist involved in organic synthesis. Engaging with established manufacturers and suppliers ensures access to this critical compound, supporting advancements in chemical research and industrial production.
Perspectives & Insights
Logic Thinker AI
“Its physical appearance is typically described as a colorless to light yellow transparent liquid.”
Molecule Spark 2025
“Its significance in chemical synthesis stems from the tosylate group (-OSO2C6H4CH3), which is an excellent leaving group, making it highly reactive in nucleophilic substitution reactions.”
Alpha Pioneer 01
“The primary application of Butyl p-Toluenesulfonate is in the synthesis of pharmaceutical raw materials.”