In the realm of pharmaceutical synthesis, specific chemical intermediates serve as the foundational building blocks for complex APIs that form the backbone of modern medicine. Among these, 4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-n-methylsulfonyl)amino]pyrimidine-5-yl-methanol, commonly identified by its CAS number 147118-36-3, stands out as a critical component, particularly in the production of statin medications like Rosuvastatin Calcium. Understanding its chemical nature and sourcing requirements is essential for any pharmaceutical manufacturer.

The Chemical Profile of CAS 147118-36-3

This intermediate is characterized by its molecular formula C16H20FN3O3S and a molecular weight of approximately 353.41 g/mol. Its physical appearance is typically a white or off-white powder, indicating a high degree of purity, often specified as ≥98%. The molecule features a pyrimidine core functionalized with a fluorophenyl group, an isopropyl substituent, and a methylsulfonylamino moiety, along with a hydroxymethyl group. These structural elements are precisely engineered to facilitate specific reactions in the subsequent synthesis steps towards the final drug substance.

Role in Cardiovascular Drug Manufacturing

The primary application of CAS 147118-36-3 lies in its use as an intermediate for Rosuvastatin Calcium. Rosuvastatin is a potent HMG-CoA reductase inhibitor, widely prescribed to lower elevated cholesterol levels and reduce the risk of cardiovascular events such as heart attack and stroke. The synthesis of Rosuvastatin involves multiple chemical steps, and intermediates like CAS 147118-36-3 are vital for achieving the correct stereochemistry and functional groups required for the drug's biological activity. Companies looking to purchase this intermediate are often engaged in the large-scale manufacturing of this essential medication.

Why Reliable Sourcing Matters

For pharmaceutical developers and manufacturers, the consistent availability of high-quality intermediates is non-negotiable. Factors to consider when sourcing CAS 147118-36-3 include:

  • Purity and Specification Compliance: Ensuring the intermediate meets the required purity of ≥98% and conforms to all specified physical and chemical properties is paramount.
  • Supplier Reliability: Partnering with a reputable manufacturer or supplier, especially one with integrated production capabilities, guarantees a stable supply chain. Suppliers in China are often sought for their manufacturing expertise and competitive pricing.
  • Regulatory Adherence: The chosen supplier should ideally adhere to international quality standards and provide comprehensive documentation, including safety data sheets (MSDS) and certificates of analysis.
  • Cost Management: While quality is key, cost-effectiveness is also a critical consideration. Purchasing from efficient manufacturers can significantly impact the overall cost of the final drug product.

By thoroughly vetting suppliers and understanding the critical nature of this pharmaceutical intermediate, companies can ensure the efficient and safe production of cardiovascular therapies, ultimately benefiting patient health.