For professionals in pharmaceutical research and development, a deep understanding of chemical intermediates is crucial for successful API synthesis. One such vital compound is identified by CAS Number 256499-19-1, commonly known as a Riociguat Intermediate. This specific chemical entity plays a pivotal role in the manufacturing process of Riociguat, a medication used to treat certain types of pulmonary hypertension. Its properties and quality directly influence the efficiency and yield of the overall synthesis pathway.

The intermediate, chemically named 1-[(2-Fluorophenyl)Methyl]-1H-Pyrazolo[3,4-b]Pyridine-3-Carboximidamide Monohydrochloride, typically presents as a cream to beige crystal or crystal powder. Its precise specifications, including molecular formula (C14H13ClFN5) and molecular weight, are critical data points for formulation scientists and process chemists. When sourcing this intermediate, it is advisable to buy from manufacturers that provide detailed technical data sheets and confirm its suitability for analytical reagents or advanced synthesis applications. The melting point, usually in the range of 247-249°C, is another indicator of its purity and consistency.

Procuring intermediates like CAS 256499-19-1 from reliable suppliers, particularly those based in China, offers distinct advantages. These advantages often include competitive pricing, large-scale production capabilities, and streamlined logistics. However, it is imperative to vet potential manufacturers thoroughly. Look for companies that not only specialize in pharmaceutical intermediates but also demonstrate a commitment to quality assurance, backed by certifications like GMP and ISO 9001. This diligence ensures that you are acquiring a product that meets the rigorous demands of pharmaceutical manufacturing.

Furthermore, engaging with a supplier that offers custom synthesis services can be highly beneficial. This allows for greater flexibility in research and development, enabling you to obtain specialized derivatives or quantities tailored to specific project needs. When you need to purchase this essential intermediate, inquire about their capacity, lead times, and any technical support they can provide. A knowledgeable supplier can be an invaluable partner in your drug development journey.

In summary, CAS 256499-19-1 is more than just a number; it represents a critical link in the pharmaceutical supply chain. By understanding its characteristics and sourcing it from reputable manufacturers, R&D scientists and procurement managers can ensure the integrity and efficiency of their Riociguat production.