In the realm of synthetic chemistry, certain molecules serve as foundational building blocks, enabling the creation of complex and functional compounds. CAS 340-05-6, commonly known as 1-Phenyl-2,2,2-trifluoroethanol, is one such indispensable intermediate. Its unique chemical structure, featuring a trifluoromethyl group adjacent to a chiral center bearing a hydroxyl and a phenyl substituent, makes it a highly sought-after reagent in various chemical sectors, particularly pharmaceuticals and advanced materials.

The physical and chemical properties of 1-Phenyl-2,2,2-trifluoroethanol are critical to its utility. Typically presenting as a colorless to brown liquid, it possesses a melting point in the range of 74.3-75.2 °C and a boiling point of 64-65 °C at a reduced pressure of 5 mm Hg. The presence of the electron-withdrawing trifluoromethyl group significantly influences the acidity of the hydroxyl proton and the reactivity of the adjacent carbon atom, facilitating a range of synthetic transformations. For chemists looking to buy this compound, understanding these properties helps in planning their reaction pathways effectively.

The primary applications for CAS 340-05-6 lie in its role as a synthetic intermediate. It is extensively used in the pharmaceutical industry to introduce the trifluoromethyl moiety into drug candidates. This group can enhance a drug's lipophilicity, which is crucial for its absorption and distribution in the body, and can also increase its metabolic stability, leading to a longer duration of action. Furthermore, the trifluoromethyl group can influence the binding affinity of a drug to its target receptor. Beyond pharmaceuticals, this compound also finds use in the synthesis of agrochemicals, specialty polymers, and other fine chemicals where fluorination is desired for specific performance characteristics.

For researchers and industrial chemists, sourcing this vital building block is a key consideration. When searching for a supplier, it is essential to look for providers who offer high purity material and can guarantee consistent product quality. Many are turning to established manufacturers in China to procure this essential fluorinated alcohol, benefiting from their production expertise and competitive pricing. Anyone planning synthesis requiring this molecule should investigate available suppliers and request quotes for their specific needs.