The Chemical Abstracts Service (CAS) Registry Number is a unique identifier for chemical substances. CAS RN 40216-83-9 refers to trans-4-Hydroxy-L-proline methyl ester hydrochloride, a compound that holds significant importance in various chemical synthesis pathways, particularly in the pharmaceutical and biotechnology sectors. Understanding its properties and applications is crucial for chemists, researchers, and procurement specialists seeking high-quality chemical raw materials.

Chemical Identity and Properties of CAS 40216-83-9

Trans-4-Hydroxy-L-proline methyl ester hydrochloride (Molecular Formula: C6H12ClNO3, Molecular Weight: 181.62) is a derivative of L-proline, an amino acid. It is characterized by a hydroxyl group at the 4th position of the pyrrolidine ring in a trans configuration relative to the carboxylate group, and the carboxylic acid has been esterified with methanol. The compound is typically supplied as a hydrochloride salt, which enhances its stability and solubility in polar solvents. Physical characteristics often include it being a white powder with a specified purity, commonly exceeding 98% as determined by analytical methods like HPLC. While detailed physical properties like boiling point and density are important, its primary value lies in its chemical reactivity and stereochemical configuration.

Applications and Significance in Synthesis

The primary utility of CAS 40216-83-9 lies in its role as a versatile chiral building block. Its well-defined stereochemistry makes it invaluable for:

  • Pharmaceutical Intermediates: It serves as a key intermediate in the synthesis of various Active Pharmaceutical Ingredients (APIs), where precise stereochemical control is essential for drug efficacy and safety. For instance, it is an intermediate in the synthesis of Teneligliptin.
  • Peptide Synthesis: As a modified proline derivative, it can be incorporated into peptide chains to impart specific structural properties, conformational rigidity, or to facilitate further functionalization.
  • Asymmetric Synthesis: It is widely used as a chiral synthon to introduce chirality into target molecules, enabling the stereoselective synthesis of complex organic compounds.

When procurement managers search for this compound, they often look for phrases like 'buy CAS 40216-83-9' or 'trans-4-Hydroxy-L-proline methyl ester hydrochloride price' to identify reliable suppliers. Understanding the CAS number is the first step in locating the exact chemical needed for specific research or manufacturing processes.

Procuring from Reliable Manufacturers

Given its importance, sourcing CAS 40216-83-9 from a reputable manufacturer is critical. Suppliers such as NINGBO INNO PHARMCHEM CO.,LTD. offer this compound with guaranteed high purity and consistent quality, catering to the stringent demands of the pharmaceutical and chemical industries. Ensuring that the product meets specifications and is sourced ethically and reliably is paramount for any buyer.