In the intricate landscape of chemical synthesis, certain molecules stand out due to their versatility and importance as building blocks for complex compounds. 3-Fluoro-2-methylphenol, identified by its CAS number 443-87-8, is one such compound. This fluorinated phenol derivative is a critical intermediate, particularly within the pharmaceutical and fine chemical industries. As a dedicated manufacturer and supplier, we aim to elucidate its significance and the importance of sourcing it from reliable partners.

The Chemical Identity of CAS 443-87-8

3-Fluoro-2-methylphenol, also known by synonyms such as 3-Fluoro-o-cresol, is characterized by its chemical formula C7H7FO and a molecular weight of 126.13 g/mol. Its unique structural features – a phenol ring substituted with a fluorine atom and a methyl group – impart specific reactivity and properties that make it invaluable in organic synthesis.

Key Properties and Applications

The physical and chemical properties of 3-Fluoro-2-methylphenol are crucial for its application. It typically appears as a colorless to light yellow liquid or solid, with a melting point around 53.2-53.9°C and a boiling point of approximately 188°C. Its predicted pKa of 9.32 ± 0.10 indicates its nature as a weak acid, characteristic of phenolic compounds.

The primary utility of 3-Fluoro-2-methylphenol lies in its role as an intermediate. It is widely employed in the preparation of sophisticated indole-like derivatives. These derivatives are of significant interest in pharmaceutical research, particularly for their potential to modulate the ROR-gamma-t pathway. Compounds targeting this pathway hold promise for the prevention and treatment of various diseases. For research scientists and product formulators, access to high-purity 3-Fluoro-2-methylphenol is therefore essential for advancing drug discovery efforts.

Why Reliable Sourcing Matters

Given its importance, sourcing CAS 443-87-8 requires careful consideration of the supplier. When you purchase 3-Fluoro-2-methylphenol, especially for sensitive applications like pharmaceutical synthesis, ensuring its quality and consistency is paramount. Relying on established manufacturers and suppliers, such as those in China with robust quality control measures, offers several advantages:

  • Guaranteed Purity: Reputable suppliers provide detailed CoAs confirming the product's purity (e.g., ≥98.0%), crucial for predictable reaction outcomes.
  • Supply Chain Security: A direct manufacturer can offer better price points and more consistent availability, mitigating risks associated with market fluctuations.
  • Technical Support: Experienced suppliers can provide technical data, safety information, and even guidance on handling and application.

When seeking to buy 3-Fluoro-2-methylphenol, prioritize manufacturers and suppliers who demonstrate transparency regarding their production processes and quality standards. This diligence ensures that your research and development projects are built upon a foundation of reliable, high-quality chemical intermediates.

Understanding the significance of CAS 443-87-8 is the first step towards leveraging its potential. Partnering with a dependable manufacturer ensures you receive the quality product needed to drive innovation in chemical synthesis and drug development.