In the realm of organic chemistry, certain molecules stand out for their versatility and utility as building blocks in the synthesis of more complex compounds. 2-Amino-4-(trifluoromethyl)phenol, identified by its CAS number 454-81-9, is one such molecule. Possessing a unique combination of functional groups—an amine, a hydroxyl, and a trifluoromethyl group on an aromatic ring—it offers chemists a powerful platform for diverse synthetic transformations. Understanding its properties and applications is key for researchers and procurement specialists in the pharmaceutical, agrochemical, and fine chemical industries.

The chemical structure of 2-Amino-4-(trifluoromethyl)phenol (C7H6F3NO) is central to its utility. The electron-donating amine and hydroxyl groups, alongside the strongly electron-withdrawing trifluoromethyl group, create specific electronic environments on the benzene ring. This arrangement influences reactivity, solubility, and the overall physiochemical properties of molecules derived from it. Its appearance is typically described as a brown crystalline powder, with a melting point around 121-122 °C, indicating its solid state at room temperature.

The trifluoromethyl group, in particular, is highly prized in medicinal chemistry and agrochemical research. Its high electronegativity and lipophilicity can significantly enhance a compound's metabolic stability, bioavailability, and target binding affinity. For example, in pharmaceutical research, CAS 454-81-9 is utilized in the synthesis of compounds that target specific enzymes or receptors. Its role as a precursor in creating potent acid ceramidase inhibitors highlights its potential in therapeutic development.

For agrochemical applications, the trifluoromethyl moiety contributes to enhanced pesticidal or herbicidal activity and improved environmental persistence. The ability to buy 2-Amino-4-(trifluoromethyl)phenol from reliable manufacturers allows agrochemical companies to explore novel active ingredients that offer better efficacy and selectivity. Sourcing this intermediate from China manufacturers often provides a competitive advantage, ensuring high purity (commonly 95% or greater) and consistent supply for both research-scale experiments and larger-scale production.

The synthesis of 2-Amino-4-(trifluoromethyl)phenol typically involves the reduction of 2-nitro-4-trifluoromethylphenol. This process, often carried out via catalytic hydrogenation, yields the desired amine product efficiently. For researchers and procurement managers looking to buy this compound, understanding its CAS number (454-81-9) is crucial for accurate identification and sourcing. Partnering with suppliers who provide comprehensive product data, including spectral analysis and purity reports, is recommended.

In summary, 2-Amino-4-(trifluoromethyl)phenol (CAS 454-81-9) is a highly versatile and valuable chemical intermediate. Its unique structural features, particularly the trifluoromethyl group, make it indispensable for advancing research in pharmaceuticals, agrochemicals, and other fine chemical applications. When seeking to acquire this important building block, engaging with experienced manufacturers, especially those based in China, offers a pathway to high-quality material at competitive prices.