In the intricate world of chemical synthesis, specific compounds emerge as indispensable building blocks, enabling the creation of complex molecules with profound applications. CAS Number 50424-28-7, commonly known as 4-Chloro-6-methoxyquinazoline, is one such compound, playing a vital role as a pharmaceutical intermediate. Understanding its properties, synthesis, and applications is crucial for researchers and procurement specialists in the chemical and pharmaceutical industries.

4-Chloro-6-methoxyquinazoline is a derivative of quinazoline, a bicyclic aromatic organic compound. Its chemical formula, C9H7ClN2O, and molecular weight of approximately 194.62 g/mol provide fundamental identifiers. Physically, it typically presents as a solid, with a reported melting point range of 107.5-108°C. While exact color descriptions can vary between suppliers, it is generally characterized as a white to off-white crystalline powder.

The chemical reactivity of 4-Chloro-6-methoxyquinazoline is significantly influenced by its structure. The chlorine atom at the 4-position is labile and readily undergoes nucleophilic substitution reactions. This makes it an excellent starting material for introducing various amine, alcohol, or thiol functionalities, facilitating the synthesis of diverse chemical entities. The methoxy group at the 6-position also contributes to its electronic properties and potential for further functionalization or modulation of biological activity.

The primary application of 4-Chloro-6-methoxyquinazoline lies in its use as a pharmaceutical intermediate. It serves as a crucial building block in the synthesis of numerous drug molecules, especially those being developed for their anticancer properties. Research into targeted cancer therapies often involves quinazoline-based scaffolds, and this intermediate provides a convenient entry point for creating such complex structures. Its role in drug discovery means that consistent availability and high purity are paramount for any buyer.

The synthesis of 4-Chloro-6-methoxyquinazoline typically involves multi-step organic reactions. While specific proprietary methods vary among manufacturers, the process requires precise control of reaction conditions to ensure product quality. For companies seeking to buy this compound, partnering with established manufacturers, particularly those in China, known for their expertise in fine chemical production, is a strategic choice. Such suppliers can offer competitive prices and ensure the necessary purity levels (e.g., 97% min) required for pharmaceutical research.

When considering a purchase, buyers should always verify the CAS number (50424-28-7) and inquire about the product's specifications, including purity, appearance, and any available analytical data. Understanding storage conditions, typically in a tightly closed container in a cool, dry, well-ventilated area, is also important for maintaining product integrity. For those in need of this essential pharmaceutical intermediate, sourcing from reliable manufacturers like NINGBO INNO PHARMCHEM CO.,LTD. guarantees access to quality materials that fuel cutting-edge research.