For professionals in the chemical and pharmaceutical industries, understanding the precise properties and application scope of key intermediates is fundamental to successful research and development. 3-Fluorophenylboronic acid, identified by its CAS number 768-35-4, is a compound of significant interest due to its versatile chemical nature and widespread utility. As a reliable manufacturer and supplier, we aim to provide comprehensive insights into this crucial organic intermediate.

Chemically, 3-Fluorophenylboronic acid (C6H6BFO2) is an organoboron compound featuring a boronic acid functional group (-B(OH)2) attached to a phenyl ring substituted with a fluorine atom at the meta position. It typically presents as an off-white to white crystalline powder, with a melting point range of approximately 214-218°C. Its molecular weight is 139.92 g/mol. The presence of both the boronic acid moiety and the electronegative fluorine atom confers unique reactivity. The boronic acid group is known for its ability to participate in various transformations, most notably the Suzuki-Miyaura cross-coupling reaction, and its capacity to reversibly bind with diols. The meta-fluorine substituent can subtly influence electron density and reactivity, making it a preferred choice for specific synthetic targets.

The applications of 3-Fluorophenylboronic acid are broad and impactful across several sectors. In organic synthesis, it is indispensable as a building block, particularly for the formation of carbon-carbon bonds via Suzuki coupling. This makes it invaluable for constructing complex organic molecules used in pharmaceuticals, agrochemicals, and advanced materials. In medicinal chemistry, it serves as a precursor for synthesizing novel drug candidates, where the fluorinated aromatic ring can enhance pharmacokinetic properties like absorption, distribution, metabolism, and excretion (ADME), as well as increase bioactivity. Furthermore, its potential use in materials science for developing functional polymers or sensor technologies is an active area of research.

For procurement managers and research scientists, sourcing 3-Fluorophenylboronic acid requires attention to purity and supplier reliability. High purity grades (e.g., ≥98.0%) are crucial to ensure the efficiency and reproducibility of synthetic processes, especially in demanding applications like pharmaceutical manufacturing. Partnering with a reputable manufacturer and supplier ensures not only the quality of the material but also a stable supply chain, competitive pricing for bulk orders, and access to necessary technical documentation such as Safety Data Sheets (SDS) and Certificates of Analysis (COA). We encourage you to inquire about our high-purity 3-Fluorophenylboronic acid and request a quote or sample to explore its potential for your projects. As a dedicated supplier, we are here to support your chemical synthesis needs.