The backbone of pharmaceutical innovation lies in the ability to synthesize complex molecules with high precision and purity. Central to this process are chemical intermediates – compounds that serve as building blocks in multi-step synthetic pathways. This article focuses on 2-Chloro-1-cyclopropyl-2-(2-fluorophenyl)ethanone, also identified by its CAS number 178688-43-2, a critical intermediate that exemplifies the quality demands in the pharmaceutical industry. Understanding its chemical characteristics and applications is vital for R&D scientists and procurement managers alike.

Chemical Identity and Properties of 178688-43-2

2-Chloro-1-cyclopropyl-2-(2-fluorophenyl)ethanone is an organic compound with the molecular formula C11H10ClFO and a molecular weight of 212.64800. Its chemical structure features a cyclopropyl ring, a chlorine atom, and a 2-fluorophenyl group attached to an ethanone backbone. Typically supplied as a white to off-white crystalline powder, its high purity (≥99%) is a prerequisite for its use in pharmaceutical synthesis. Key physical and chemical properties, such as its density (1.316 g/cm³) and boiling point (274.058ºC), are important for process design and handling. For researchers and buyers, detailed specifications from a reliable manufacturer are essential for evaluating its suitability.

Applications in Pharmaceutical Synthesis

The primary application for 2-Chloro-1-cyclopropyl-2-(2-fluorophenyl)ethanone lies in its role as a key intermediate in the synthesis of Prasugrel Hydrochloride. Prasugrel is a potent P2Y12 inhibitor, widely prescribed to prevent thrombotic events in patients with coronary artery disease. The successful synthesis of this life-saving drug relies heavily on the consistent quality and availability of its precursors. Pharmaceutical manufacturers seeking to produce Prasugrel Hydrochloride will actively search for suppliers providing this intermediate, often looking for specific product names or CAS numbers like '178688-43-2' to ensure they are sourcing the correct material. Reliable sourcing involves confirming specifications like purity and appearance to guarantee optimal reaction outcomes.

Sourcing and Procurement Considerations

For R&D scientists and procurement specialists, sourcing intermediates like 2-Chloro-1-cyclopropyl-2-(2-fluorophenyl)ethanone involves identifying reputable manufacturers and suppliers. Companies often look for partners who can offer not only high-quality products but also competitive pricing and a stable supply chain. Inquiries for 'prasugrel intermediate price' or '2-chloro-1-cyclopropyl-2-(2-fluorophenyl)ethanone supplier' are common. Engaging with manufacturers who provide detailed technical data, regulatory support, and efficient logistics is crucial for a smooth procurement process. By understanding the chemical nuances and application significance of this intermediate, companies can make informed decisions, ensuring the integrity and efficiency of their pharmaceutical manufacturing operations.